Wave Life Sciences Ltd.
Chiral design
Last updated:
Abstract:
The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.
Status:
Grant
Type:
Utility
Filling date:
22 Aug 2018
Issue date:
27 Oct 2020