Wave Life Sciences Ltd.
Chiral design

Last updated:

Abstract:

The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.

Status:
Grant
Type:

Utility

Filling date:

22 Aug 2018

Issue date:

27 Oct 2020