Wave Life Sciences Ltd.
OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF

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Abstract:

Among other things, the present disclosure provides oligonucleotides, compositions, and methods for preventing and/or treating various conditions, disorders or diseases. In some embodiments, provided oligonucleotides comprise nucleobase modifications, sugar modifications, internucleotidic linkage modifications and/or patterns thereof, and have improved properties, activities and/or selectivities. In some embodiments, the present disclosure provides oligonucleotides, compositions and methods for HTT-related conditions, disorders or diseases, such as Huntington's disease.

Status:
Application
Type:

Utility

Filling date:

30 Jan 2020

Issue date:

31 Mar 2022