XBiotech Inc.
Compositions and Methods for Treating and Preventing Staphylococcus Aureus Infections

Abstract:

Methods and compositions for treating a Staphylococcus aureus bloodstream infection in a human subject involve administering to the subject an antibody which specifically binds Staphylococcus aureus protein A (SpA) with a KD of less than 1.times.10.sup.-10 M via its Fab region paratope and is able to mediate opsinization of SpA-expressing Staphylococcus aureus bacteria in the presence of at least 1 mg/ml of IgG immunoglobulins which bind SpA via their Fc regions.