Acceleron Pharma Inc.
BI-AND TRI-FUNCTIONAL FUSION PROTEINS AND USES THEREOF

Abstract:

Disclosed herein are bi- and tri-functional fusion proteins comprising two or more of an activin antagonist domain, a TOP.beta. antagonist domain, and an immune checkpoint antagonist domain. In addition, the disclosure provides methods of treating cancer, a tumor, a pre-neoplastic disorder, a hyperproliferative disorder, or a dysplastic disorder comprising administering a bi- or tri-functional fusion protein comprising two or more of an activin antagonist domain, a TOP.beta. antagonist domain, and an immune checkpoint antagonist domain. Optionally, such methods further comprise administering an additional active agent or supportive therapy for treating the cancer, a tumor, a pre-neoplastic disorder, a hyperproliferative disorder, or a dysplastic disorder.