Acceleron Pharma Inc.
COMPOSITIONS AND METHODS FOR TREATING SPINAL MUSCULAR ATROPHY

Abstract:

In certain aspects, the disclosure provides compositions and methods for treating spinal muscular atrophy. For example, in some embodiments, the disclosure provides ALK4:ActRIIB antagonists that may be used to treat spinal muscular atrophy, particularly treating one or more complications of spinal muscular atrophy including, for example, increasing muscle mass muscle strength, and bone mineral density.