Xencor, Inc.
IL-15/IL-15RA HETERODIMERIC FC FUSION PROTEINS AND USES THEREOF

Abstract:

The present invention is directed to novel IL-15/IL-15R.alpha. heterodimeric Fc fusion proteins and uses thereof. The IL-15/IL-15R.alpha. heterodimeric Fc fusion proteins can be administered to a patient to treat cancer. In some cases, the IL-15/IL-15R.alpha. heterodimeric Fc fusion protein is administered in combination with a checkpoint blockage antibody such as a PD-1 antibody.