Xencor, Inc.
HETERODIMERIC ANTIBODIES THAT BIND TGFbetaRII

Abstract:

Provided herein are novel antibodies that bind TGF RII and methods of making and using such antibodies. The antibodies provided advantageously block TGF activity in a broad population of cells (e.g., active and unactivated hematopoietic cells), and find use wherein such blockage of TGF activity is desirable, for example, for the treatment of cancers. In some embodiments, the antibodies are novel .alpha.TGF RII.times..alpha.CD5 and .alpha.TGF RII.times..alpha.PD-1 bispecific antibodies.