Xencor, Inc.
Methods and compositions for inhibiting CD32B expressing cells in IGG4-related diseases

Abstract:

The present disclosure relates to immunoglobulins that bind Fc.gamma.RIIb+ B cells and coengage CD19 on the cell's surface and an Fc.gamma.RIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins for the treatment of an IgG4-related disease.