Zealand Pharma A/S
Cyclic peptides targeting alpha-4-beta-7 integrin

Abstract:

There is described herein antagonists of .alpha.4.beta.7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; --C.dbd.O-- adjacent L is the carboxy terminus of an amino acid; and L along with Z and --C.dbd.O-- is a peptide. ##STR00001##