| Utility: METHODS AND COMPOSITIONS FOR TREATING A PROPROTEIN CONVERTASE SUBTILISIN KEXIN (PCSK9) GENE-ASSOCIATED DISORDER Filling date: 9 Sep 2025 Issue date: 3 Jun 2021 | 15 Jul 2020 | 3 Jun 2021 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF CD274/PD-L1 GENE Filling date: 9 Sep 2025 Issue date: 27 May 2021 | 7 Jul 2020 | 27 May 2021 |
| Utility: APOLIPOPROTEIN C3 (APOC3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 15 Apr 2021 | 21 Dec 2020 | 15 Apr 2021 |
| Utility: ANGIOTENSINOGEN (AGT) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 1 Apr 2021 | 10 Nov 2020 | 1 Apr 2021 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE LECT2 GENE Filling date: 9 Sep 2025 Issue date: 1 Apr 2021 | 13 Jul 2020 | 1 Apr 2021 |
| Utility: OLIGONUCLEOTIDES COMPRISING ACYCLIC AND ABASIC NUCLEOSIDES AND ANALOGS Filling date: 9 Sep 2025 Issue date: 25 Mar 2021 | 3 Dec 2020 | 25 Mar 2021 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE Filling date: 9 Sep 2025 Issue date: 25 Mar 2021 | 4 Jun 2020 | 25 Mar 2021 |
| Utility: COMPOSITIONS AND METHODS DIRECTED TO TREATING LIVER FIBROSIS Filling date: 9 Sep 2025 Issue date: 25 Mar 2021 | 6 May 2020 | 25 Mar 2021 |
| Utility: ANGIOTENSINOGEN (AGT) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 18 Feb 2021 | 15 Sep 2020 | 18 Feb 2021 |
| Utility: SERPINA1 SIRNAS: COMPOSITIONS OF MATTER AND METHODS OF TREATMENT Filling date: 9 Sep 2025 Issue date: 11 Feb 2021 | 26 Oct 2020 | 11 Feb 2021 |
| Utility: MODIFIED DOUBLE-STRANDED RNA AGENTS Filling date: 9 Sep 2025 Issue date: 21 Jan 2021 | 25 Nov 2019 | 21 Jan 2021 |
| Utility: STEROL REGULATORY ELEMENT BINDING PROTEIN (SREBP) CHAPERONE (SCAP) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 7 Jan 2021 | 27 Jul 2020 | 7 Jan 2021 |
| Utility: TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 17 Dec 2020 | 18 Aug 2020 | 17 Dec 2020 |
| Utility: POLYNUCLEOTIDE AGENTS TARGETING ANGIOTENSINOGEN (AGT) AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 10 Dec 2020 | 20 Aug 2020 | 10 Dec 2020 |
| Utility: KISSPEPTIN 1 (KISS1) IRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 10 Dec 2020 | 15 Nov 2018 | 10 Dec 2020 |
| Utility: TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES Filling date: 9 Sep 2025 Issue date: 3 Dec 2020 | 1 May 2020 | 3 Dec 2020 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MUTANT EGFR GENE Filling date: 9 Sep 2025 Issue date: 3 Dec 2020 | 3 Mar 2020 | 3 Dec 2020 |
| Utility: MODIFIED RNAi AGENTS Filling date: 9 Sep 2025 Issue date: 12 Nov 2020 | 16 Apr 2020 | 12 Nov 2020 |
| Utility: SERUM AMYLOID P COMPONENT (APCS) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 5 Nov 2020 | 19 May 2020 | 5 Nov 2020 |
| Utility: COMPLEMENT COMPONENT iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 29 Oct 2020 | 10 Jul 2020 | 29 Oct 2020 |
| Utility: AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENT COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 29 Oct 2020 | 9 Jul 2020 | 29 Oct 2020 |
| Utility: ASSAYS AND METHODS FOR DETERMINING EXPRESSION OF THE LECT2 GENE Filling date: 9 Sep 2025 Issue date: 29 Oct 2020 | 8 Nov 2018 | 29 Oct 2020 |
| Utility: Dual Targeting siRNA Agents Filling date: 9 Sep 2025 Issue date: 22 Oct 2020 | 27 Feb 2020 | 22 Oct 2020 |
| Utility: RNAI AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING TRANSTHYRETIN (TTR) ASSOCIATED DISEASES Filling date: 9 Sep 2025 Issue date: 8 Oct 2020 | 9 Jan 2020 | 8 Oct 2020 |
| Utility: Compositions and Methods for Inhibiting Expression of the PCSK9 Gene Filling date: 9 Sep 2025 Issue date: 8 Oct 2020 | 5 Nov 2019 | 8 Oct 2020 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITION OF HAO1 (HYDROXYACID OXIDASE 1 (GLYCOLATE OXIDASE)) GENE EXPRESSION Filling date: 9 Sep 2025 Issue date: 8 Oct 2020 | 4 Nov 2019 | 8 Oct 2020 |
| Utility: HIGH MOBILITY GROUP BOX-1 (HMGB1) IRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 1 Oct 2020 | 18 Dec 2018 | 1 Oct 2020 |
| Utility: CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES Filling date: 9 Sep 2025 Issue date: 24 Sep 2020 | 29 Apr 2020 | 24 Sep 2020 |
| Utility: XANTHINE DEHYDROGENASE (XDH) IRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 24 Sep 2020 | 27 Jan 2020 | 24 Sep 2020 |
| Utility: METHODS AND COMPOSITIONS FOR DETECTING ANTI-DRUG ANTIBODIES Filling date: 9 Sep 2025 Issue date: 17 Sep 2020 | 28 Feb 2020 | 17 Sep 2020 |
| Utility: HEPATITIS D VIRUS (HDV) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 17 Sep 2020 | 26 Feb 2020 | 17 Sep 2020 |
| Utility: Compositions and Methods for Inhibiting Expression of Transthyretin Filling date: 9 Sep 2025 Issue date: 10 Sep 2020 | 23 Jan 2020 | 10 Sep 2020 |
| Utility: INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN, ACID LABILE SUBUNIT (IGFALS) AND INSULIN-LIKE GROWTH FACTOR 1 (IGF-1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 3 Sep 2020 | 15 Oct 2019 | 3 Sep 2020 |
| Utility: Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes Filling date: 9 Sep 2025 Issue date: 20 Aug 2020 | 2 Dec 2019 | 20 Aug 2020 |
| Utility: COMPLEMENT COMPONENT iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 20 Aug 2020 | 18 Sep 2019 | 20 Aug 2020 |
| Utility: THERAPEUTIC COMPOSITIONS Filling date: 9 Sep 2025 Issue date: 13 Aug 2020 | 22 Apr 2020 | 13 Aug 2020 |
| Utility: POLYNUCLEOTIDE AGENTS TARGETING PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 6 Aug 2020 | 14 Feb 2020 | 6 Aug 2020 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITIION OF EXPRESSION OF PROTEIN C (PROC) GENES Filling date: 9 Sep 2025 Issue date: 30 Jul 2020 | 11 Nov 2019 | 30 Jul 2020 |
| Utility: LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF SERUM AMYLOID A GENE Filling date: 9 Sep 2025 Issue date: 30 Jul 2020 | 3 Oct 2019 | 30 Jul 2020 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR V Filling date: 9 Sep 2025 Issue date: 23 Jul 2020 | 4 Nov 2019 | 23 Jul 2020 |
| Utility: ANGIOPOIETIN-LIKE 3 (ANGPTL3) IRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 16 Jul 2020 | 12 Dec 2019 | 16 Jul 2020 |
| Utility: LACTATE DEHYDROGENASE A (LDHA) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 2 Jul 2020 | 6 Mar 2020 | 2 Jul 2020 |
| Utility: METHODS FOR TREATING OR PREVENTING CONTACT-ACTIVATION PATHWAY-ASSOCIATED DISEASES USING iRNA COMPOSITIONS TARGETING FACTOR XII (HAGEMAN FACTOR) (F12) Filling date: 9 Sep 2025 Issue date: 2 Jul 2020 | 6 Jul 2018 | 2 Jul 2020 |
| Utility: siRNA Therapy for Transthyretin (TTR) Related Ocular Amyloidosis Filling date: 9 Sep 2025 Issue date: 25 Jun 2020 | 9 Sep 2019 | 25 Jun 2020 |
| Utility: APOLIPOPROTEIN C3 (APOC3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 25 Jun 2020 | 7 Aug 2019 | 25 Jun 2020 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE Filling date: 9 Sep 2025 Issue date: 11 Jun 2020 | 17 Jul 2019 | 11 Jun 2020 |
| Utility: KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 4 Jun 2020 | 19 Jun 2019 | 4 Jun 2020 |
| Utility: Methods For Inhibition Of HAO1 (Hydroxyacid Oxidase 1 (Glycolate Oxidase)) Gene Expression Filling date: 9 Sep 2025 Issue date: 28 May 2020 | 12 Jul 2018 | 28 May 2020 |
| Utility: METHODS AND COMPOSITIONS FOR TREATING A PROPROTEIN CONVERTASE SUBTILISIN KEXIN (PCSK9) GENE-ASSOCIATED DISORDER Filling date: 9 Sep 2025 Issue date: 7 May 2020 | 16 Jan 2020 | 7 May 2020 |
| Utility: HEPATITIS B VIRUS (HBV) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 9 Sep 2025 Issue date: 7 May 2020 | 4 Nov 2019 | 7 May 2020 |
