| Utility: Compositions and methods for inhibition of HAO1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression Filling date: 8 Sep 2025 Issue date: 20 Sep 2022 | 4 Nov 2019 | 20 Sep 2022 |
| Utility: Sterol regulatory element binding protein (SREBP) chaperone (SCAP) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 6 Sep 2022 | 27 Jul 2020 | 6 Sep 2022 |
| Utility: Modified double-stranded RNA agents Filling date: 8 Sep 2025 Issue date: 30 Aug 2022 | 10 Nov 2021 | 30 Aug 2022 |
| Utility: Angiotensinogen (AGT) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 23 Aug 2022 | 15 Sep 2020 | 23 Aug 2022 |
| Utility: Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 9 Aug 2022 | 15 Jun 2021 | 9 Aug 2022 |
| Utility: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 19 Apr 2022 | 22 Nov 2021 | 19 Apr 2022 |
| Utility: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 19 Apr 2022 | 22 Nov 2021 | 19 Apr 2022 |
| Utility: Endosomal cleavable linkers Filling date: 8 Sep 2025 Issue date: 29 Mar 2022 | 18 Jan 2018 | 29 Mar 2022 |
| Utility: Methods for inhibition of HAO1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression Filling date: 8 Sep 2025 Issue date: 1 Mar 2022 | 12 Jul 2018 | 1 Mar 2022 |
| Utility: Biodegradable lipids for the delivery of active agents Filling date: 8 Sep 2025 Issue date: 15 Feb 2022 | 29 Apr 2021 | 15 Feb 2022 |
| Utility: Serum amyloid P component (APCS) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 25 Jan 2022 | 19 May 2020 | 25 Jan 2022 |
| Utility: Coronavirus iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 28 Dec 2021 | 17 May 2021 | 28 Dec 2021 |
| Utility: High density lipoprotein binding protein (Hdlbp/Vigilin) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 28 Dec 2021 | 17 Oct 2018 | 28 Dec 2021 |
| Utility: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 14 Dec 2021 | 12 Dec 2019 | 14 Dec 2021 |
| Utility: Compositions and methods for inhibiting expression of TMPRSS6 gene Filling date: 8 Sep 2025 Issue date: 14 Dec 2021 | 4 Sep 2018 | 14 Dec 2021 |
| Utility: Complement component iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 30 Nov 2021 | 18 Sep 2019 | 30 Nov 2021 |
| Utility: Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 2 Nov 2021 | 22 Feb 2021 | 2 Nov 2021 |
| Utility: Complement component C5 iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 2 Nov 2021 | 7 May 2019 | 2 Nov 2021 |
| Utility: Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 19 Oct 2021 | 23 Feb 2021 | 19 Oct 2021 |
| Utility: Lipid formulated compositions and methods for inhibiting expression of serum amyloid A gene Filling date: 8 Sep 2025 Issue date: 19 Oct 2021 | 3 Oct 2019 | 19 Oct 2021 |
| Utility: Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 12 Oct 2021 | 7 Aug 2019 | 12 Oct 2021 |
| Utility: Ketohexokinase (KHK) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 5 Oct 2021 | 19 Jun 2019 | 5 Oct 2021 |
| Utility: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 28 Sep 2021 | 26 Jan 2021 | 28 Sep 2021 |
| Utility: Compositions and methods for inhibition of expression of protein C (PROC) genes Filling date: 8 Sep 2025 Issue date: 14 Sep 2021 | 11 Nov 2019 | 14 Sep 2021 |
| Utility: Carbohydrate conjugates as delivery agents for oligonucleotides Filling date: 8 Sep 2025 Issue date: 7 Sep 2021 | 29 Apr 2020 | 7 Sep 2021 |
| Utility: Methods of treating transthyretin (TTR) mediated amyloidosis Filling date: 8 Sep 2025 Issue date: 3 Aug 2021 | 3 Aug 2018 | 3 Aug 2021 |
| Utility: Biodegradable lipids for the delivery of active agents Filling date: 8 Sep 2025 Issue date: 27 Jul 2021 | 23 Jul 2019 | 27 Jul 2021 |
| Utility: Insulin-like growth factor binding protein, acid labile subunit (IGFALS) and insulin-like growth factor 1 (IGF-1) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 20 Jul 2021 | 15 Oct 2019 | 20 Jul 2021 |
| Utility: Hepatitis B virus (HBV) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 13 Jul 2021 | 4 Nov 2019 | 13 Jul 2021 |
| Utility: Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 6 Jul 2021 | 5 Feb 2019 | 6 Jul 2021 |
| Utility: Multi-targeted single entity conjugates Filling date: 8 Sep 2025 Issue date: 6 Jul 2021 | 15 Jul 2016 | 6 Jul 2021 |
| Utility: Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 15 Jun 2021 | 21 Dec 2020 | 15 Jun 2021 |
| Utility: Amyloid precursor protein (APP) RNAi agent compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 15 Jun 2021 | 9 Jul 2020 | 15 Jun 2021 |
| Utility: Compositions and methods for inhibiting expression of the ALAS1 gene Filling date: 8 Sep 2025 Issue date: 8 Jun 2021 | 20 Sep 2018 | 8 Jun 2021 |
| Utility: Angiotensinogen (AGT) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 25 May 2021 | 10 Nov 2020 | 25 May 2021 |
| Utility: iRNA agents with biocleavable tethers Filling date: 8 Sep 2025 Issue date: 25 May 2021 | 23 Jul 2018 | 25 May 2021 |
| Utility: Serpina1 iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 4 May 2021 | 23 May 2019 | 4 May 2021 |
| Utility: TMPRSS6 iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 27 Apr 2021 | 18 Aug 2020 | 27 Apr 2021 |
| Utility: Conserved HBV and HCV sequences useful for gene silencing Filling date: 8 Sep 2025 Issue date: 20 Apr 2021 | 27 Apr 2018 | 20 Apr 2021 |
| Utility: Polynucleotide agents targeting programmed cell death 1 ligand 1 (PD-L1) and methods of use thereof Filling date: 8 Sep 2025 Issue date: 20 Apr 2021 | 9 Dec 2016 | 20 Apr 2021 |
| Utility: Polynucleotide agents targeting aminolevulinic acid synthase-1 (ALAS1) and uses thereof Filling date: 8 Sep 2025 Issue date: 6 Apr 2021 | 30 Mar 2017 | 6 Apr 2021 |
| Utility: GNAQ targeted dsRNA compositions and methods for inhibiting expression Filling date: 8 Sep 2025 Issue date: 23 Mar 2021 | 3 Apr 2018 | 23 Mar 2021 |
| Utility: Polynucleotide agents targeting hydroxyacid oxidase (glycolate oxidase, HAO1) and methods of use thereof Filling date: 8 Sep 2025 Issue date: 16 Mar 2021 | 14 Dec 2017 | 16 Mar 2021 |
| Utility: Serpina1 siRNAs: compositions of matter and methods of treatment Filling date: 8 Sep 2025 Issue date: 2 Mar 2021 | 17 Jul 2019 | 2 Mar 2021 |
| Utility: Factor XII (hageman factor) (F12), kallikrein B, plasma (fletcher factor) 1 (KLKB1), and kininogen 1 (KNG1) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 2 Mar 2021 | 24 May 2019 | 2 Mar 2021 |
| Utility: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 2 Mar 2021 | 14 May 2019 | 2 Mar 2021 |
| Utility: Myostatin iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 2 Mar 2021 | 20 Sep 2017 | 2 Mar 2021 |
| Utility: Serpina1 iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 16 Feb 2021 | 14 Jun 2018 | 16 Feb 2021 |
| Utility: TMPRSS6 iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 9 Feb 2021 | 15 Nov 2018 | 9 Feb 2021 |
| Utility: Programmed cell death 1 ligand 1 (PD-L1) iRNA compositions and methods of use thereof Filling date: 8 Sep 2025 Issue date: 12 Jan 2021 | 22 Aug 2016 | 12 Jan 2021 |
