Vertex Pharmaceuticals Incorporated
Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors

Abstract:

Described herein are methods of treating a proliferative disease in a subject by administering a DNA-damaging agent and between about 8 and about 48 hours later administering to the subject a DNA-PK inhibitor. Exemplary DNA-PK inhibitors are represented by Formula (B-I): and by pharmaceutically acceptable salts thereof, wherein R.sup.1, Q, Ring A, and Ring B are as defined herein. ##STR00001##