| Utility: Modulators of cystic fibrosis transmembrane conductance regulator Filling date: 12 Sep 2025 Issue date: 30 Aug 2022 | 31 Mar 2020 | 30 Aug 2022 |
| Utility: MATERIALS AND METHODS FOR TREATMENT OF HEMOGLOBINOPATHIES Filling date: 12 Sep 2025 Issue date: 18 Aug 2022 | 26 Jan 2022 | 18 Aug 2022 |
| Utility: METHOD FOR TREATING CANCER USING A COMBINATION OF CHK1 AND ATR INHIBITORS Filling date: 12 Sep 2025 Issue date: 11 Aug 2022 | 20 Sep 2021 | 11 Aug 2022 |
| Utility: ENHANCED DIFFERENTIATION OF BETA CELLS Filling date: 12 Sep 2025 Issue date: 28 Jul 2022 | 23 Dec 2021 | 28 Jul 2022 |
| Utility: COMPOSITIONS AND METHODS FOR EDITING BETA-GLOBIN FOR TREATMENT OF HEMAGLOBINOPATHIES Filling date: 12 Sep 2025 Issue date: 21 Jul 2022 | 17 Dec 2021 | 21 Jul 2022 |
| Utility: MATERIALS AND METHODS FOR TREATMENT OF HEMOGLOBINOPATHIES Filling date: 12 Sep 2025 Issue date: 7 Jul 2022 | 2 Feb 2022 | 7 Jul 2022 |
| Utility: Compounds useful as inhibitors of ATR kinase Filling date: 12 Sep 2025 Issue date: 28 Jun 2022 | 31 Aug 2020 | 28 Jun 2022 |
| Utility: Compositions and Methods for Treatment of Disorders Associated with Repetitive DNA Filling date: 12 Sep 2025 Issue date: 16 Jun 2022 | 25 Feb 2022 | 16 Jun 2022 |
| Utility: Methods of preparing inhibitors of influenza viruses replication Filling date: 12 Sep 2025 Issue date: 31 May 2022 | 9 Mar 2020 | 31 May 2022 |
| Utility: METHODS, COMPOSITIONS AND KITS FOR INCREASING GENOME EDITING EFFICIENCY Filling date: 12 Sep 2025 Issue date: 7 Apr 2022 | 20 Aug 2021 | 7 Apr 2022 |
| Utility: Modulators of Cystic Fibrosis Transmembrane Conductance Regulator, Pharmaceutical Compositions, Methods of Treatment, and Process for Making the Modulators Filling date: 12 Sep 2025 Issue date: 7 Apr 2022 | 18 May 2021 | 7 Apr 2022 |
| Utility: Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- -3-carboxamide Filling date: 12 Sep 2025 Issue date: 5 Apr 2022 | 5 Dec 2019 | 5 Apr 2022 |
| Utility: Compositions and Methods for Treatment of Duchenne Muscular Dystrophy Filling date: 12 Sep 2025 Issue date: 31 Mar 2022 | 8 Sep 2021 | 31 Mar 2022 |
| Utility: DIFFERENTIATION OF PANCREATIC ENDOCRINE CELLS Filling date: 12 Sep 2025 Issue date: 24 Mar 2022 | 30 Jul 2021 | 24 Mar 2022 |
| Utility: METHOD FOR TREATING CANCER USING A COMBINATION OF DNA-DAMAGING AGENTS AND DNA-PK INHIBITORS Filling date: 12 Sep 2025 Issue date: 24 Mar 2022 | 29 Jul 2021 | 24 Mar 2022 |
| Utility: Materials and methods for treatment of hemoglobinopathies Filling date: 12 Sep 2025 Issue date: 8 Mar 2022 | 5 Feb 2019 | 8 Mar 2022 |
| Utility: Methods of treatment for cystic fibrosis Filling date: 12 Sep 2025 Issue date: 22 Feb 2022 | 8 Jun 2018 | 22 Feb 2022 |
| Utility: METHODS OF TREATMENT FOR CYSTIC FIBROSIS Filling date: 12 Sep 2025 Issue date: 17 Feb 2022 | 13 Nov 2019 | 17 Feb 2022 |
| Utility: MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Filling date: 12 Sep 2025 Issue date: 10 Feb 2022 | 6 Aug 2021 | 10 Feb 2022 |
| Utility: PHARMACEUTICAL COMPOSITIONS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL) CYCLOPROPANECARBOXAMIDO)-3-METHYLPYRIDIN-2-YL) BENZOIC ACID AND ADMINISTRATION THEREOF Filling date: 12 Sep 2025 Issue date: 3 Feb 2022 | 28 May 2021 | 3 Feb 2022 |
| Utility: GENE-EDITING SYSTEMS FOR EDITING A CYSTIC FIBROSIS TRANSMEMBRANE REGULATOR (CFTR) GENE Filling date: 12 Sep 2025 Issue date: 30 Dec 2021 | 4 Jun 2021 | 30 Dec 2021 |
| Utility: Sulfonamides as modulators of sodium channels Filling date: 12 Sep 2025 Issue date: 21 Dec 2021 | 18 Jul 2014 | 21 Dec 2021 |
| Utility: Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator Filling date: 12 Sep 2025 Issue date: 30 Nov 2021 | 4 Dec 2019 | 30 Nov 2021 |
| Utility: Pharmaceutical compositions for treating cystic fibrosis Filling date: 12 Sep 2025 Issue date: 23 Nov 2021 | 4 Feb 2019 | 23 Nov 2021 |
| Utility: Method for treating cancer using a combination of Chk1 and ATR inhibitors Filling date: 12 Sep 2025 Issue date: 23 Nov 2021 | 17 Jun 2015 | 23 Nov 2021 |
| Utility: Crystalline forms and compositions of CFTR modulators Filling date: 12 Sep 2025 Issue date: 26 Oct 2021 | 25 Mar 2020 | 26 Oct 2021 |
| Utility: Pharmaceutical composition and administrations thereof Filling date: 12 Sep 2025 Issue date: 19 Oct 2021 | 12 Mar 2019 | 19 Oct 2021 |
| Utility: MATERIALS AND METHODS FOR TREATMENT OF HEMOGLOBINOPATHIES Filling date: 12 Sep 2025 Issue date: 14 Oct 2021 | 23 Jun 2020 | 14 Oct 2021 |
| Utility: Methods, compositions and kits for increasing genome editing efficiency Filling date: 12 Sep 2025 Issue date: 21 Sep 2021 | 13 Jul 2017 | 21 Sep 2021 |
| Utility: Compounds useful as inhibitors of ATR kinase Filling date: 12 Sep 2025 Issue date: 14 Sep 2021 | 6 Aug 2019 | 14 Sep 2021 |
| Utility: Compounds useful as inhibitors of ATR kinase and combination therapies thereof Filling date: 12 Sep 2025 Issue date: 7 Sep 2021 | 10 Jul 2019 | 7 Sep 2021 |
| Utility: Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors Filling date: 12 Sep 2025 Issue date: 7 Sep 2021 | 27 Sep 2017 | 7 Sep 2021 |
| Utility: Modulators of ATP-binding cassette transporters Filling date: 12 Sep 2025 Issue date: 10 Aug 2021 | 13 Feb 2020 | 10 Aug 2021 |
| Utility: Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulators Filling date: 12 Sep 2025 Issue date: 20 Jul 2021 | 14 Feb 2019 | 20 Jul 2021 |
| Utility: Pteridinone compounds and uses thereof Filling date: 12 Sep 2025 Issue date: 13 Jul 2021 | 23 Apr 2019 | 13 Jul 2021 |
| Utility: Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid and administration thereof Filling date: 12 Sep 2025 Issue date: 6 Jul 2021 | 2 Aug 2019 | 6 Jul 2021 |
| Utility: SUBSTITUTED TETRAHYDROFURANS AS MODULATORS OF SODIUM CHANNELS Filling date: 12 Sep 2025 Issue date: 1 Jul 2021 | 4 Dec 2020 | 1 Jul 2021 |
| Utility: METHODS OF ENHANCING STEM CELL DIFFERENTIATION INTO BETA CELLS Filling date: 12 Sep 2025 Issue date: 1 Jul 2021 | 2 Sep 2020 | 1 Jul 2021 |
| Utility: METHODS OF CANCER TREATMENT USING AN ATR INHIBITOR Filling date: 12 Sep 2025 Issue date: 1 Jul 2021 | 27 Dec 2018 | 1 Jul 2021 |
| Utility: MODULATORS OF ALPHA-1 ANTITRYPSIN Filling date: 12 Sep 2025 Issue date: 17 Jun 2021 | 4 Oct 2019 | 17 Jun 2021 |
| Utility: MATERIALS AND METHODS FOR TREATMENT OF HEMOGLOBINOPATHIES Filling date: 12 Sep 2025 Issue date: 17 Jun 2021 | 26 Oct 2018 | 17 Jun 2021 |
| Utility: DNA-PK inhibitors Filling date: 12 Sep 2025 Issue date: 1 Jun 2021 | 16 Oct 2019 | 1 Jun 2021 |
| Utility: DEUTERATED PYRIDONE AMIDES AND PRODRUGS THEREOF AS MODULATORS OF SODIUM CHANNELS Filling date: 12 Sep 2025 Issue date: 27 May 2021 | 16 May 2018 | 27 May 2021 |
| Utility: DNA-PK inhibitors Filling date: 12 Sep 2025 Issue date: 18 May 2021 | 13 Aug 2019 | 18 May 2021 |
| Utility: MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Filling date: 12 Sep 2025 Issue date: 13 May 2021 | 5 Apr 2019 | 13 May 2021 |
| Utility: GCN2 inhibitors and uses thereof Filling date: 12 Sep 2025 Issue date: 27 Apr 2021 | 28 Jan 2019 | 27 Apr 2021 |
| Utility: Modulators of ATP-binding cassette transporters Filling date: 12 Sep 2025 Issue date: 27 Apr 2021 | 10 Apr 2018 | 27 Apr 2021 |
| Utility: METHODS OF TREATMENT FOR CYSTIC FIBROSIS Filling date: 12 Sep 2025 Issue date: 22 Apr 2021 | 8 Jun 2018 | 22 Apr 2021 |
| Utility: Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases Filling date: 12 Sep 2025 Issue date: 20 Apr 2021 | 26 Dec 2018 | 20 Apr 2021 |
| Utility: Substituted quinoxaline DNA-PK inhibitors Filling date: 12 Sep 2025 Issue date: 13 Apr 2021 | 1 Apr 2019 | 13 Apr 2021 |
