Vertex Pharmaceuticals Incorporated
DIFFERENTIATION OF PANCREATIC ENDOCRINE CELLS

Abstract:

Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic .beta. cell, .alpha. cell, .delta. cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.