Vertex Pharmaceuticals Incorporated
Methods of preparing inhibitors of influenza viruses replication

Abstract:

A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: ##STR00001## comprises: (a) reacting Compound (X): ##STR00002## or a pharmaceutically acceptable salt thereof with Compound (Y): ##STR00003## in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): ##STR00004## or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.