Vertex Pharmaceuticals Incorporated
Substituted quinoxaline DNA-PK inhibitors

Abstract:

The present invention relates to Provided are compounds of Formula (I): ##STR00001## wherein R.sup.1, R.sup.2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.