Vertex Pharmaceuticals Incorporated
Modulators of cystic fibrosis transmembrane conductance regulator

Abstract:

The present disclosure features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R.sub.1, R.sub.2, W, X, Z, n, p, and Rings A and B are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present disclosure also features pharmaceutical compositions, method of treating, and kits thereof. ##STR00001##