| Utility: TREATMENT OF PARKINSON'S DISEASE AND OTHER CONDITIONS CAUSED OR MEDIATED BY SENESCENT ASTROCYTES USING SMALL MOLECULE SENOLYTIC AGENTS Filling date: 8 Sep 2025 Issue date: 31 Mar 2022 | 10 Dec 2021 | 31 Mar 2022 |
| Utility: Methods of Inhibiting Pathological Angiogenesis Filling date: 8 Sep 2025 Issue date: 10 Mar 2022 | 25 Aug 2021 | 10 Mar 2022 |
| Utility: Acyl Sulfonamides that are BCL Family Antagonists for Use in Clinical Management of Conditions Caused or Mediated by Senescent Cells and for Treating Cancer Filling date: 8 Sep 2025 Issue date: 20 Jan 2022 | 3 Jun 2021 | 20 Jan 2022 |
| Utility: Killing Senescent Cells And Treating Senescence-Associated Conditions Using A Bcl Inhibitor And An Mcl-1 Inhibitor Filling date: 8 Sep 2025 Issue date: 9 Dec 2021 | 24 Oct 2019 | 9 Dec 2021 |
| Utility: Methods of inhibiting pathological angiogenesis Filling date: 8 Sep 2025 Issue date: 28 Sep 2021 | 14 Feb 2020 | 28 Sep 2021 |
| Utility: Acylsulfonamide derivatives for treating senescence-associated diseases and disorders Filling date: 8 Sep 2025 Issue date: 7 Sep 2021 | 16 Dec 2016 | 7 Sep 2021 |
| Utility: TREATING LIVER DISEASE BY SELECTIVELY ELIMINATING SENESCENT CELLS Filling date: 8 Sep 2025 Issue date: 10 Jun 2021 | 7 Dec 2020 | 10 Jun 2021 |
| Utility: TREATING CARDIOVASCULAR DISEASE BY SELECTIVELY ELIMINATING SENESCENT CELLS Filling date: 8 Sep 2025 Issue date: 10 Jun 2021 | 7 Dec 2020 | 10 Jun 2021 |
| Utility: ANTIBODIES DIRECTED TO TIE-2 AND METHODS OF USE Filling date: 8 Sep 2025 Issue date: 27 May 2021 | 19 Nov 2020 | 27 May 2021 |
| Utility: Acyl sulfonamides that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer Filling date: 8 Sep 2025 Issue date: 20 Apr 2021 | 10 Jun 2020 | 20 Apr 2021 |
| Utility: Phospholidines that are Bcl Family Antagonists for Use in Clinical Management of Conditions Caused or Mediated by Senescent Cells and for Treating Cancer Filling date: 8 Sep 2025 Issue date: 11 Mar 2021 | 2 Jul 2020 | 11 Mar 2021 |
| Utility: TREATING COGNITIVE DECLINE AND OTHER NEURODEGENERATIVE CONDITIONS BY SELECTIVELY REMOVING SENESCENT CELLS FROM NEUROLOGICAL TISSUE Filling date: 8 Sep 2025 Issue date: 4 Feb 2021 | 8 Oct 2020 | 4 Feb 2021 |
| Utility: Phosphonamidates that are BCL Family Antagonists for Use in Clinical Management of Conditions Caused or Mediated by Senescent Cells and for Treating Cancer Filling date: 8 Sep 2025 Issue date: 24 Dec 2020 | 2 Jul 2020 | 24 Dec 2020 |
| Utility: Acyl Sulfonamides that are BCL Family Antagonists for Use in Clinical Management of Conditions Caused or Mediated by Senescent Cells and for Treating Cancer Filling date: 8 Sep 2025 Issue date: 17 Dec 2020 | 29 May 2020 | 17 Dec 2020 |
| Utility: COMPOSITION COMPRISING A GENE VECTOR THAT SELECTIVELY DEPLETES P16 POSITIVE SENESCENT CELLS Filling date: 8 Sep 2025 Issue date: 26 Nov 2020 | 20 Dec 2019 | 26 Nov 2020 |
| Utility: Inhibitors of HSP90, PI3-Kinase, Proteasome, HDAC, and P97 Pathways for Selective Removal of Senescent Cells in the Treatment of Age Related Conditions Filling date: 8 Sep 2025 Issue date: 19 Nov 2020 | 28 Dec 2018 | 19 Nov 2020 |
| Utility: Treatment of Lung Diseases Using Pharmaceutical Agents that Eliminate Senescent Cells Filling date: 8 Sep 2025 Issue date: 12 Nov 2020 | 13 Aug 2018 | 12 Nov 2020 |
| Utility: USE OF A HETEROCYCLIC BCL-2 INHIBITOR FOR REMOVING SENESCENT CELLS AND TREATING SENESCENCE-ASSOCIATED CONDITIONS Filling date: 8 Sep 2025 Issue date: 29 Oct 2020 | 11 Jun 2020 | 29 Oct 2020 |
| Utility: Use of a Heterocyclic Bcl-xL Inhibitor and Related Analogs for Removing Senescent Cells in the Treatment of Eye Diseases and Other Age-Related Conditions Filling date: 8 Sep 2025 Issue date: 29 Oct 2020 | 4 Jun 2020 | 29 Oct 2020 |
| Utility: Acyl Sulfonamides that are BCL Family Antagonists for Use in Clinical Management of Conditions Caused or Mediated by Senescent Cells and for Treating Cancer Filling date: 8 Sep 2025 Issue date: 8 Oct 2020 | 10 Jun 2020 | 8 Oct 2020 |
| Utility: ACYLSULFONAMIDE DERIVATIVES FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS Filling date: 8 Sep 2025 Issue date: 17 Sep 2020 | 16 Dec 2016 | 17 Sep 2020 |
| Utility: Phospholidines that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer Filling date: 8 Sep 2025 Issue date: 18 Aug 2020 | 29 May 2019 | 18 Aug 2020 |
| Utility: Conjugates that are configured for targeted delivery of therapeutic compounds to senescent cells Filling date: 8 Sep 2025 Issue date: 18 Aug 2020 | 27 Mar 2018 | 18 Aug 2020 |
| Utility: Methods of Inhibiting Pathological Angiogenesis Filling date: 8 Sep 2025 Issue date: 13 Aug 2020 | 14 Feb 2020 | 13 Aug 2020 |
| Utility: Acyl sulfonamides that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer Filling date: 8 Sep 2025 Issue date: 21 Jul 2020 | 19 Jun 2019 | 21 Jul 2020 |
| Utility: Acyl phosphonamidates and acyl benzylamines that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer Filling date: 8 Sep 2025 Issue date: 7 Jul 2020 | 29 May 2019 | 7 Jul 2020 |
| Utility: Treatment of Lung Diseases Using Pharmaceutical Agents that Eliminate Senescent Cells Filling date: 8 Sep 2025 Issue date: 25 Jun 2020 | 13 Aug 2018 | 25 Jun 2020 |
| Utility: Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer Filling date: 8 Sep 2025 Issue date: 23 Jun 2020 | 24 Apr 2019 | 23 Jun 2020 |
| Utility: Technology to inhibit vascular changes that lead to vision loss in the eye Filling date: 8 Sep 2025 Issue date: 17 Mar 2020 | 15 Oct 2018 | 17 Mar 2020 |
| Utility: CHEMICAL ENTITIES THAT KILL SENESCENT CELLS FOR USE IN TREATING AGE-RELATED DISEASE Filling date: 8 Sep 2025 Issue date: 5 Mar 2020 | 20 Sep 2019 | 5 Mar 2020 |
| Utility: Composition comprising a gene vector that selectively depletes P16 positive senescent cells Filling date: 8 Sep 2025 Issue date: 4 Feb 2020 | 10 Jun 2019 | 4 Feb 2020 |
| Utility: TREATING COGNITIVE DECLINE AND OTHER NEURODEGENERATIVE CONDITIONS BY SELECTIVELY REMOVING SENESCENT CELLS FROM NEUROLOGICAL TISSUE Filling date: 8 Sep 2025 Issue date: 30 Jan 2020 | 26 Sep 2019 | 30 Jan 2020 |
| Utility: Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer Filling date: 8 Sep 2025 Issue date: 2 Jan 2020 | 12 Aug 2019 | 2 Jan 2020 |
| Utility: Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer Filling date: 8 Sep 2025 Issue date: 31 Dec 2019 | 12 Aug 2019 | 31 Dec 2019 |
| Utility: Removing senescent cells from a mixed cell population or tissue using a phosphoinositide 3-kinase (PI3K) inhibitor Filling date: 8 Sep 2025 Issue date: 31 Dec 2019 | 16 May 2018 | 31 Dec 2019 |
| Utility: Acyl Sulfonamides that are BCL Family Antagonists for Use in Clinical Management of Conditions Caused or Mediated by Senescent Cells and for Treating Cancer Filling date: 8 Sep 2025 Issue date: 19 Dec 2019 | 19 Jun 2019 | 19 Dec 2019 |
| Utility: Unit dose of an aryl sulfonamide that is effective for treating eye disease and averting potential vision loss Filling date: 8 Sep 2025 Issue date: 19 Nov 2019 | 13 Jun 2018 | 19 Nov 2019 |
| Utility: Compositions of matter for treatment of ophthalmic conditions by selectively removing senescent cells from the eye Filling date: 8 Sep 2025 Issue date: 19 Nov 2019 | 18 Apr 2018 | 19 Nov 2019 |
| Utility: THERAPY FOR REMOVING SENESCENT CELLS AND TREATING SENESCENCE-ASSOCIATED DISEASE USING AN MDM2 INHIBITOR Filling date: 8 Sep 2025 Issue date: 14 Nov 2019 | 10 Jul 2019 | 14 Nov 2019 |
| Utility: COMPOSITION COMPRISING A GENE VECTOR THAT SELECTIVELY DEPLETES P16 POSITIVE SENESCENT CELLS Filling date: 8 Sep 2025 Issue date: 17 Oct 2019 | 10 Jun 2019 | 17 Oct 2019 |
| Utility: Chemical entities that kill senescent cells for use in treating age-related disease Filling date: 8 Sep 2025 Issue date: 1 Oct 2019 | 8 Mar 2018 | 1 Oct 2019 |
| Utility: Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders using an inhibitor of Akt kinase Filling date: 8 Sep 2025 Issue date: 17 Sep 2019 | 11 Apr 2018 | 17 Sep 2019 |
| Utility: PRODUCTS OF CHIRAL SYNTHESIS OF CIS-IMIDAZOLINE COMPOUNDS AND THEIR USE Filling date: 8 Sep 2025 Issue date: 5 Sep 2019 | 17 May 2019 | 5 Sep 2019 |
| Utility: TREATMENT OF PARKINSON'S DISEASE AND OTHER CONDITIONS CAUSED OR MEDIATED BY SENESCENT ASTROCYTES USING SMALL MOLECULE SENOLYTIC AGENTS Filling date: 8 Sep 2025 Issue date: 5 Sep 2019 | 3 May 2019 | 5 Sep 2019 |
| Utility: Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer Filling date: 8 Sep 2025 Issue date: 15 Aug 2019 | 24 Apr 2019 | 15 Aug 2019 |
| Utility: Replication conditional virus that specifically kills senescent cells Filling date: 8 Sep 2025 Issue date: 13 Aug 2019 | 6 Jul 2018 | 13 Aug 2019 |
