Purchase
WALKER NEAL director, officer: President and CEO director, officer: President an..
Common Stock 10,000 $16.75 $167,500 Option
MOLINEAUX CHRISTOPHER P. director director
Common Stock 2,377 $0.88 $2,099 Option
MOLINEAUX CHRISTOPHER P. director director
Stock option (right to buy) 2,377 $0.75 $1,776 Option
MOLINEAUX CHRISTOPHER P. director director
Common Stock 2,377 $0.75 $1,776 Option
MOLINEAUX CHRISTOPHER P. director director
Stock option (right to buy) 2,377 $0.88 $2,099 Option
WALKER NEAL director, officer: President and CEO director, officer: President an..
Common Stock 2,925 N/A N/A Option
ALI-JACKSON KAMIL officer: Chief Legal Officer officer: Chief Legal Officer
Restricted Stock Units 1,075 N/A N/A Option
RUFFO FRANK officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 1,250 N/A N/A Option
WALKER NEAL director, officer: President and CEO director, officer: President an..
Restricted Stock Units 2,925 N/A N/A Option
POWALA CHRISTOPHER officer: Chief Reg & Develop Officer officer: Chief Reg & Develop Of..
Common Stock 1,625 N/A N/A Option
POWALA CHRISTOPHER officer: Chief Reg & Develop Officer officer: Chief Reg & Develop Of..
Restricted Stock Units 1,625 N/A N/A Option
SHANLER STUART officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,450 N/A N/A Option
ALI-JACKSON KAMIL officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 1,075 N/A N/A Option
SHANLER STUART officer: Chief Scientific Officer officer: Chief Scientific Officer
Restricted Stock Units 1,450 N/A N/A Option
RUFFO FRANK officer: Chief Financial Officer officer: Chief Financial Officer
Restricted Stock Units 1,250 N/A N/A Option
WALKER NEAL director, officer: President and CEO director, officer: President an..
Restricted Stock Units 3,033 N/A N/A Option
RUFFO FRANK officer: Chief Financial Officer officer: Chief Financial Officer
Restricted Stock Units 1,300 N/A N/A Option
WALKER NEAL director, officer: President and CEO director, officer: President an..
Common Stock 3,033 N/A N/A Option
SHANLER STUART officer: Chief Scientific Officer officer: Chief Scientific Officer
Restricted Stock Units 1,300 N/A N/A Option
POWALA CHRISTOPHER officer: Chief Reg & Develop Officer officer: Chief Reg & Develop Of..
Restricted Stock Units 1,300 N/A N/A Option
RUFFO FRANK officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 1,300 N/A N/A Option
ALI-JACKSON KAMIL officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 1,733 N/A N/A Option
POWALA CHRISTOPHER officer: Chief Reg & Develop Officer officer: Chief Reg & Develop Of..
Common Stock 1,300 N/A N/A Option
ALI-JACKSON KAMIL officer: Chief Legal Officer officer: Chief Legal Officer
Restricted Stock Units 1,733 N/A N/A Option
SHANLER STUART officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,300 N/A N/A Purchase
SCHIFF ANDREW N director director
Common Stock 108,601 $23.02 $2,499,995 Option
MOLINEAUX CHRISTOPHER P. director director
Common Stock 7,605 $0.75 $5,681 Option
MOLINEAUX CHRISTOPHER P. director director
Common Stock 7,605 $0.88 $6,715 Option
MOLINEAUX CHRISTOPHER P. director director
Stock option (right to buy) 7,605 $0.88 $6,715 Option
MOLINEAUX CHRISTOPHER P. director director
Stock option (right to buy) 7,605 $0.75 $5,681 Sale
VIVO VENTURES VII, LLC 10 percent owner 10 percent owner
Common Stock 125,000 $31.2 $3,900,000 Sale
VIVO VENTURES VII, LLC 10 percent owner 10 percent owner
Common Stock 100,000 $30.98 $3,098,000 Sale
VIVO VENTURES VII, LLC 10 percent owner 10 percent owner
Common Stock 200,000 $30.5 $6,100,000 Sale
MEHRA ANAND director director
Common Stock 750,000 $28.25 $21,188,250 Option
POWALA CHRISTOPHER officer: Chief Reg & Develop Officer officer: Chief Reg & Develop Of..
Common Stock 1,625 N/A N/A Option
WALKER NEAL director, officer: President and CEO director, officer: President an..
Common Stock 2,925 N/A N/A Option
ALI-JACKSON KAMIL officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 1,075 N/A N/A Option
SHANLER STUART officer: Chief Scientific Officer officer: Chief Scientific Officer
Restricted Stock Units 1,450 N/A N/A Option
POWALA CHRISTOPHER officer: Chief Reg & Develop Officer officer: Chief Reg & Develop Of..
Restricted Stock Units 1,625 N/A N/A Option
WALKER NEAL director, officer: President and CEO director, officer: President an..
Restricted Stock Units 2,925 N/A N/A Option
ALI-JACKSON KAMIL officer: Chief Legal Officer officer: Chief Legal Officer
Restricted Stock Units 1,075 N/A N/A Option
RUFFO FRANK officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 1,250 N/A N/A Option
SHANLER STUART officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,450 N/A N/A Option
RUFFO FRANK officer: Chief Financial Officer officer: Chief Financial Officer
Restricted Stock Units 1,250 N/A N/A Sale
VIVO VENTURES VII, LLC 10 percent owner 10 percent owner
Common Stock 450,000 $22.72 $10,224,000 Sale
VIVO VENTURES VII, LLC 10 percent owner 10 percent owner
Common Stock 457,828 $25.28 $11,571,603 Sale
ALI-JACKSON KAMIL officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 3,912 N/A N/A Option
ALI-JACKSON KAMIL officer: Chief Legal Officer officer: Chief Legal Officer
Employee StockOption (right to buy) 3,912 N/A N/A Sale
FMR LLC other: See Remark 1 other: See Remark 1
Common Stock 3,750 $22.04 $82,650 Option
ALI-JACKSON KAMIL officer: Chief Legal Officer officer: Chief Legal Officer
Common Stock 3,912 N/A N/A