Alnylam Pharmaceuticals, Inc.
Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof

Abstract:

The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ANGPTL3 gene, as well as methods of inhibiting expression of ANGPTL3 and methods of treating subjects having a disorder of lipid metabolism, such as hyperlipidemia or hypertriglyceridemia, using such dsRNA compositions.