| Utility: METHODS FOR TREATING OR PREVENTING CONTACT-ACTIVATION PATHWAY-ASSOCIATED DISEASES USING iRNA COMPOSITIONS TARGETING FACTOR XII (HAGEMAN FACTOR) (F12) Filling date: 5 Sep 2025 Issue date: 25 Aug 2022 | 28 Sep 2021 | 25 Aug 2022 |
| Utility: REVERSIR TM COMPOUNDS Filling date: 5 Sep 2025 Issue date: 18 Aug 2022 | 10 Aug 2021 | 18 Aug 2022 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF TMPRSS6 GENE Filling date: 5 Sep 2025 Issue date: 11 Aug 2022 | 26 Oct 2021 | 11 Aug 2022 |
| Utility: Methods of Treating Transthyretin (TTR) Mediated Amyloidosis Filling date: 5 Sep 2025 Issue date: 11 Aug 2022 | 14 Sep 2021 | 11 Aug 2022 |
| Utility: Modified RNAi agents Filling date: 5 Sep 2025 Issue date: 9 Aug 2022 | 16 Apr 2020 | 9 Aug 2022 |
| Utility: LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF SERUM AMYLOID A GENE Filling date: 5 Sep 2025 Issue date: 4 Aug 2022 | 14 Sep 2021 | 4 Aug 2022 |
| Utility: Biodegradable lipids for the delivery of active agents Filling date: 5 Sep 2025 Issue date: 2 Aug 2022 | 12 Jan 2022 | 2 Aug 2022 |
| Utility: Modified double-stranded RNA agents Filling date: 5 Sep 2025 Issue date: 2 Aug 2022 | 25 Nov 2019 | 2 Aug 2022 |
| Utility: ANGIOPOIETIN-LIKE 3 (ANGPTL3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 28 Jul 2022 | 6 Apr 2022 | 28 Jul 2022 |
| Utility: Carboxypeptidase B2 (CPB2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 21 Jul 2022 | 31 Jan 2022 | 21 Jul 2022 |
| Utility: Biodegradable lipids for the delivery of active agents Filling date: 5 Sep 2025 Issue date: 12 Jul 2022 | 17 Dec 2021 | 12 Jul 2022 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE LECT2 GENE Filling date: 5 Sep 2025 Issue date: 7 Jul 2022 | 2 Aug 2021 | 7 Jul 2022 |
| Utility: BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS Filling date: 5 Sep 2025 Issue date: 9 Jun 2022 | 14 Feb 2022 | 9 Jun 2022 |
| Utility: POLYNUCLEOTIDE AGENTS TARGETING COMPLEMENT COMPONENT C5 AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 26 May 2022 | 28 Jun 2021 | 26 May 2022 |
| Utility: SERPINA1 SIRNAS: COMPOSITIONS OF MATTER AND METHODS OF TREATMENT Filling date: 5 Sep 2025 Issue date: 19 May 2022 | 5 Oct 2021 | 19 May 2022 |
| Utility: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof Filling date: 5 Sep 2025 Issue date: 17 May 2022 | 5 Nov 2020 | 17 May 2022 |
| Utility: Xanthine dehydrogenase (XDH) iRNA compositions and methods of use thereof Filling date: 5 Sep 2025 Issue date: 10 May 2022 | 20 Oct 2021 | 10 May 2022 |
| Utility: Methods for the treatment of subjects having a hepatitis b virus (HBV) infection Filling date: 5 Sep 2025 Issue date: 10 May 2022 | 18 Apr 2018 | 10 May 2022 |
| Utility: Xanthine dehydrogenase (XDH) IRNA compositions and methods of use thereof Filling date: 5 Sep 2025 Issue date: 3 May 2022 | 27 Jan 2020 | 3 May 2022 |
| Utility: KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 28 Apr 2022 | 2 Sep 2021 | 28 Apr 2022 |
| Utility: REVERSIR TM COMPOUNDS Filling date: 5 Sep 2025 Issue date: 28 Apr 2022 | 10 Aug 2021 | 28 Apr 2022 |
| Utility: EXTRAHEPATIC DELIVERY Filling date: 5 Sep 2025 Issue date: 28 Apr 2022 | 7 May 2019 | 28 Apr 2022 |
| Utility: Modified iRNA agents Filling date: 5 Sep 2025 Issue date: 26 Apr 2022 | 26 Jul 2019 | 26 Apr 2022 |
| Utility: ANGIOPOIETIN-LIKE 3 (ANGPTL3) IRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 21 Apr 2022 | 3 Nov 2021 | 21 Apr 2022 |
| Utility: Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof Filling date: 5 Sep 2025 Issue date: 19 Apr 2022 | 22 Nov 2021 | 19 Apr 2022 |
| Utility: Transthyretin (TTR) iRNA compositions and methods of use thereof for treating or preventing TTR-associated diseases Filling date: 5 Sep 2025 Issue date: 29 Mar 2022 | 1 May 2020 | 29 Mar 2022 |
| Utility: COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 24 Mar 2022 | 12 Jul 2021 | 24 Mar 2022 |
| Utility: ANGIOPOIETIN-LIKE 3 (ANGPTL3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 10 Mar 2022 | 22 Nov 2021 | 10 Mar 2022 |
| Utility: ANGIOPOIETIN-LIKE 3 (ANGPTL3) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 10 Mar 2022 | 22 Nov 2021 | 10 Mar 2022 |
| Utility: MODIFIED DOUBLE-STRANDED RNA AGENTS Filling date: 5 Sep 2025 Issue date: 24 Feb 2022 | 10 Nov 2021 | 24 Feb 2022 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITION OF EXPRESSION OF APOLIPOPROTEIN C-III (APOC3) GENES Filling date: 5 Sep 2025 Issue date: 17 Feb 2022 | 24 Jun 2021 | 17 Feb 2022 |
| Utility: INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN, ACID LABILE SUBUNIT (IGFALS) AND INSULIN-LIKE GROWTH FACTOR 1 (IGF-1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 10 Feb 2022 | 17 Jun 2021 | 10 Feb 2022 |
| Utility: CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES Filling date: 5 Sep 2025 Issue date: 13 Jan 2022 | 6 Jul 2021 | 13 Jan 2022 |
| Utility: AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENT COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 6 Jan 2022 | 7 May 2021 | 6 Jan 2022 |
| Utility: POLYNUCLEOTIDE AGENTS TARGETING AMINOLEVULINIC ACID SYNTHASE-1 (ALAS1) AND USES THEREOF Filling date: 5 Sep 2025 Issue date: 6 Jan 2022 | 23 Feb 2021 | 6 Jan 2022 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE PCSK9 GENE Filling date: 5 Sep 2025 Issue date: 30 Dec 2021 | 26 Feb 2021 | 30 Dec 2021 |
| Utility: POLYNUCLEOTIDE AGENTS TARGETING HYDROXYACID OXIDASE (GLYCOLATE OXIDASE, HAO1) AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 30 Dec 2021 | 3 Feb 2021 | 30 Dec 2021 |
| Utility: SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 14 Oct 2021 | 5 Jan 2021 | 14 Oct 2021 |
| Utility: POLYNUCLEOTIDE AGENTS TARGETING PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 14 Oct 2021 | 9 Nov 2020 | 14 Oct 2021 |
| Utility: LACTATE DEHYDROGENASE A (LDHA) iRNA COMPOSITIONS AND METHODS OF USE THEREOF Filling date: 5 Sep 2025 Issue date: 29 Jul 2021 | 30 Nov 2020 | 29 Jul 2021 |
