Purchase
VON RICKENBACH JOSEF H director director
Common Stock 88,145 $0.98 $86,294 Purchase
VON RICKENBACH JOSEF H director director
Common Stock 23,225 $0.71 $16,583 Purchase
VON RICKENBACH JOSEF H director director
Common Stock 13,466 $0.7 $9,426 Purchase
VON RICKENBACH JOSEF H director director
Common Stock 15,000 $0.73 $10,965 Purchase
VON RICKENBACH JOSEF H director director
Common Stock 3,600 $0.77 $2,772 Purchase
VUKOVIC VOJO officer: SVP, Chief Medical Officer officer: SVP, Chief Medical Off..
Common Stock 75,000 $0.59 $44,475 Purchase
GREGORY KATHRYN officer: SVP, Chief Business Officer officer: SVP, Chief Business Of..
Common Stock 45,000 $0.65 $29,025 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 20,610 $1.9 $39,159 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 106,540 $1.85 $197,099 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 43,800 $1.92 $84,096 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 13,800 $1.88 $25,944 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 132,738 $2.12 $281,405 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 20,388 $2.3 $46,892 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 8,700 $2.1 $18,270 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 8,808 $2.1 $18,497 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 2,635 $2.15 $5,665 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 3,300 $2.26 $7,458 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 1,600 $2.36 $3,776 Purchase
LONGENECKER JOHN P PHD officer: President and CEO officer: President and CEO
Common Stock 10,000 $2.45 $24,500 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 5,615 $2.44 $13,701 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 235 $2.48 $583 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 1,000 $2.78 $2,780 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 1,739 $2.97 $5,165 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 2,942 $3.02 $8,885 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 4,702 $3.33 $15,658 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 8,181 $3.22 $26,343 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 4,500 $3.07 $13,815 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 2,000 $3.27 $6,540 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 6,458 $3.38 $21,828 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 7,937 $3.63 $28,811 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 12,460 $3.84 $47,846 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 700 $4.11 $2,877 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 30,600 $4.25 $130,050 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 12,500 $4.71 $58,875 Sale
NOVARTIS BIOVENTURES LTD 10 percent owner 10 percent owner
Common Stock 300 $5.15 $1,545 Sale
APPLE TREE PARTNERS II LP 10 percent owner 10 percent owner
Common Stock 10,528 $5.46 $57,430 Sale
APPLE TREE PARTNERS II LP 10 percent owner 10 percent owner
Common Stock 913 $5.86 $5,353 Sale
APPLE TREE PARTNERS II LP 10 percent owner 10 percent owner
Common Stock 94,816 $5.98 $566,715 Sale
APPLE TREE PARTNERS II LP 10 percent owner 10 percent owner
Common Stock 1,447 $5.3 $7,669 Sale
APPLE TREE PARTNERS II LP 10 percent owner 10 percent owner
Common Stock 5,200 $5.3 $27,565 Sale
APPLE TREE PARTNERS II LP 10 percent owner 10 percent owner
Common Stock 139 $5.3 $737 Sale
APPLE TREE PARTNERS II LP 10 percent owner 10 percent owner
Common Stock 1,432 $5.35 $7,661 Sale
APPLE TREE PARTNERS II LP 10 percent owner 10 percent owner
Common Stock 7,961 $5.32 $42,345 Sale
APPLE TREE PARTNERS II LP 10 percent owner 10 percent owner
Common Stock 10,843 $5.4 $58,563 Sale
APPLE TREE PARTNERS II LP 10 percent owner 10 percent owner
Common Stock 18,525 $5.41 $100,239 Purchase
DOUGHERTY DONALD officer: SVP & Chief Financial Officer officer: SVP & Chief Financial ..
Common Stock 3,000 $5.4 $16,200 Sale
APPLE TREE PARTNERS II LP 10 percent owner 10 percent owner
Common Stock 9,617 $5.4 $51,961 Sale
APPLE TREE PARTNERS II LP 10 percent owner 10 percent owner
Common Stock 20 $5.48 $110 Purchase
AIVADO MANUEL director, officer: See Remarks director, officer: See Remarks
Common Stock 1,000 $5.61 $5,610 Purchase
DOUGHERTY DONALD officer: SVP & Chief Financial Officer officer: SVP & Chief Financial ..
Common Stock 2,000 $5.24 $10,480