Sale
WATSON DAVID O. officer: General Counsel officer: General Counsel
Common Stock 3,000 $40.47 $121,401 Option
WATSON DAVID O. officer: General Counsel officer: General Counsel
Common Stock 15,000 $2.67 $40,050 Option
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 30,637 $2.14 $65,563 Option
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Stock Option (Right to Buy) 30,637 $2.14 $65,563 Option
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 30,638 $2.14 $65,565 Option
MACHIELS ALEC director director
Common Stock 2,500 $2.67 $6,675 Option
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Stock Option (Right to Buy) 30,638 $2.14 $65,565 Option
MACHIELS ALEC director director
Stock Option (Right to Buy) 2,500 $2.67 $6,675 Sale
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 35,638 $42.06 $1,498,899 Sale
MACHIELS ALEC director director
Common Stock 2,500 $2.67 $6,675 Purchase
MORNINGSIDE VENTURE INVESTMENTS LTD 10 percent owner 10 percent owner
Common Stock 540,540 $37 $19,999,980 Sale
DUNLOP A. SINCLAIR director director
Common Stock 25,000 $29.53 $738,250 Sale
DUNLOP A. SINCLAIR director director
Common Stock 85,110 $29.25 $2,489,468 Sale
DUNLOP A. SINCLAIR director director
Common Stock 25,890 $28.55 $739,160 Sale
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 5,000 $27.95 $139,750 Sale
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 5,000 $27.28 $136,405 Sale
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 5,000 $26.1 $130,500 Sale
DESCHATELETS PASCAL officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 21,541 $25.44 $548,003 Sale
DESCHATELETS PASCAL officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 21,602 $24.76 $534,866 Sale
DESCHATELETS PASCAL officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 20,858 $25.3 $527,687 Sale
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 5,000 $26.86 $134,320 Purchase
SULLIVAN TIMOTHY EUGENE officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 11,699 $29.72 $347,636 Option
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 37,505 $2.67 $100,138 Option
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Stock Option (Right to Buy) 37,505 $2.67 $100,138 Sale
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 10,000 $26.87 $268,720 Option
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 10,000 $2.14 $21,400 Option
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Stock Option (Right to Buy) 10,000 $2.14 $21,400 Option
WATSON DAVID O. officer: General Counsel officer: General Counsel
Common Stock 5,000 $2.67 $13,350 Option
WATSON DAVID O. officer: General Counsel officer: General Counsel
Stock Option (Right to Buy) 5,000 $2.67 $13,350 Option
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 275,000 $2.14 $588,500 Option
FRANCOIS CEDRIC director, officer: Chief Executive Officer director, officer: Chief Execut..
Stock Option (Right to Buy) 275,000 $2.14 $588,500 Purchase
MORNINGSIDE VENTURE INVESTMENTS LTD 10 percent owner 10 percent owner
Common Stock 441,176 $17 $7,499,992 Option
AXON STEVEN officer: Chief Business Officer officer: Chief Business Officer
Stock Option (Right to Buy) 11,500 $2.59 $29,785 Option
GROSSI FEDERICO officer: CHIEF MEDICAL OFFICER officer: CHIEF MEDICAL OFFICER
Common Stock 6,250 $3.2 $20,000 Option
GROSSI FEDERICO officer: CHIEF MEDICAL OFFICER officer: CHIEF MEDICAL OFFICER
Stock Option (Right to Buy) 6,250 $3.2 $20,000 Option
AXON STEVEN officer: Chief Business Officer officer: Chief Business Officer
Common Stock 11,500 $2.59 $29,785 Purchase
MORNINGSIDE VENTURE INVESTMENTS LTD 10 percent owner 10 percent owner
Common Stock 40,000 $19.84 $793,600 Purchase
MORNINGSIDE VENTURE INVESTMENTS LTD 10 percent owner 10 percent owner
Common Stock 41,323 $19.11 $789,683 Purchase
MORNINGSIDE VENTURE INVESTMENTS LTD 10 percent owner 10 percent owner
Common Stock 60,000 $18.09 $1,085,400 Purchase
MORNINGSIDE VENTURE INVESTMENTS LTD 10 percent owner 10 percent owner
Common Stock 40,000 $18.47 $738,800 Purchase
MORNINGSIDE VENTURE INVESTMENTS LTD 10 percent owner 10 percent owner
Common Stock 40,000 $18.67 $746,800 Option
WATSON DAVID O. officer: General Counsel officer: General Counsel
Common Stock 32,818 $2.67 $87,624 Option
WATSON DAVID O. officer: General Counsel officer: General Counsel
Stock Option (right to buy) 32,818 $2.67 $87,624 Sale
WATSON DAVID O. officer: General Counsel officer: General Counsel
Common Stock 15,776 $18.78 $296,336 Option
WATSON DAVID O. officer: General Counsel officer: General Counsel
Common Stock 624 $2.67 $1,666 Option
WATSON DAVID O. officer: General Counsel officer: General Counsel
Stock Option (right to buy) 624 $2.67 $1,666 Purchase
SCHEIBLER LUKAS officer: CHIEF INNOVATION OFFICER officer: CHIEF INNOVATION OFFICER
Common Stock 2,935 $20.37 $59,786 Option
GROSSI FEDERICO officer: CHIEF MEDICAL OFFICER officer: CHIEF MEDICAL OFFICER
Stock Option (right to buy) 8,500 $3.2 $27,200 Option
GROSSI FEDERICO officer: CHIEF MEDICAL OFFICER officer: CHIEF MEDICAL OFFICER
Common Stock 8,500 $3.2 $27,200 Option
AXON STEVEN officer: Chief Business Officer officer: Chief Business Officer
Stock Option (right to buy) 38,610 $2.59 $100,000 
