Option
ESHELMAN FREDRIC N other: See Footnote (1) other: See Footnote (1)
Pre-Funded Warrant (right to buy) 4,545,455 N/A N/A Option
ESHELMAN FREDRIC N other: See Footnote (1) other: See Footnote (1)
Common Stock 4,545,455 N/A N/A Option
GIACCIA AMATO director director
Stock Option 39,261 $0.24 $9,423 Sale
GIACCIA AMATO director director
Common Stock 3,245 $3.22 $10,449 Option
GIACCIA AMATO director director
Common Stock 51,611 $0.18 $9,290 Purchase
SHAH VINAY officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 1,000 N/A N/A Purchase
MCINTYRE GAIL FRANCES director, officer: CEO and President director, officer: CEO and Pres..
Common Stock 1,000 N/A N/A Option
GIACCIA AMATO director director
Common Stock 12,083 N/A N/A Option
GIACCIA AMATO director director
Stock Option (Right to buy) 8,055 N/A N/A Purchase
SHAH VINAY officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 8,000 $5.76 $46,080 Purchase
MCINTYRE GAIL FRANCES director, officer: CEO and President director, officer: CEO and Pres..
Common Stock 8,000 $5.77 $46,160 Purchase
AKKARAJU SRINIVAS other: Former Director other: Former Director
Common Stock 133,333 $7.5 $999,998 Sale
SHEPARD JAY other: Former Director other: Former Director
Common Stock 4,004 $6.82 $27,295 Sale
SHEPARD JAY other: Former Director other: Former Director
Common Stock 1,192 $6.11 $7,283 Sale
SHEPARD JAY other: Former Director other: Former Director
Common Stock 2,163 $4.14 $8,955 Sale
HAAS KEVIN officer: VP, Finance and PAO officer: VP, Finance and PAO
Common Stock 204 $4.14 $845 Sale
HAAS KEVIN officer: VP, Finance and PAO officer: VP, Finance and PAO
Common Stock 204 $4.14 $845 Sale
SHEPARD JAY other: Former Director other: Former Director
Common Stock 2,163 $4.14 $8,955 Sale
SHEPARD JAY other: Former Director other: Former Director
Common Stock 3,484 $3.22 $11,232 Sale
HAAS KEVIN officer: VP, Finance and PAO officer: VP, Finance and PAO
Common Stock 711 $3.22 $2,292 Sale
HAAS KEVIN officer: VP, Finance and PAO officer: VP, Finance and PAO
Common Stock 711 N/A N/A Sale
SHEPARD JAY other: Former Director other: Former Director
Common Stock 11,247 $3.96 $44,561 Sale
HAAS KEVIN officer: VP, Finance and PAO officer: VP, Finance and PAO
Common Stock 1,164 $3.96 $4,612 Sale
HAAS KEVIN officer: VP, Finance and PAO officer: VP, Finance and PAO
Common Stock 143 $2.3 $329 Sale
WESTBERG PAUL officer: SVP and Chief Business Officer officer: SVP and Chief Business..
Common Stock 612 $2.3 $1,408 Purchase
AKKARAJU SRINIVAS other: Former Director other: Former Director
Common Stock 53,018 $2.13 $112,928 Purchase
AKKARAJU SRINIVAS other: Former Director other: Former Director
Common Stock 231,580 $2 $463,160 Purchase
AKKARAJU SRINIVAS other: Former Director other: Former Director
Common Stock 163,224 $1.85 $301,964 Purchase
AKKARAJU SRINIVAS other: Former Director other: Former Director
Common Stock 660,681 $1.74 $1,149,585 Sale
SHEPARD JAY other: Former Director other: Former Director
Common Stock 9,232 $1.5 $13,848 Sale
STOUT JAY S officer: SVP, Technical Operations officer: SVP, Technical Operati..
Common Stock 4,854 $1.55 $7,524 Sale
WOODY TRACY M officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 4,345 $1.75 $7,604 Sale
SHEPARD JAY other: Former Director other: Former Director
Common Stock 14,446 $1.8 $26,003 Sale
HAAS KEVIN officer: VP, Finance and PAO officer: VP, Finance and PAO
Common Stock 1,599 $1.8 $2,878 Sale
WARD SHANE officer: SVP and General Counsel officer: SVP and General Counsel
Common Stock 4,118 $1.8 $7,412 Sale
WESTBERG PAUL officer: SVP and Chief Business Officer officer: SVP and Chief Business..
Common Stock 5,355 $1.8 $9,639 Purchase
AKKARAJU SRINIVAS other: Former Director other: Former Director
Common Stock 42,895 $2 $85,790 Purchase
AKKARAJU SRINIVAS other: Former Director other: Former Director
Common Stock 513,872 $2.21 $1,135,657 Purchase
AKKARAJU SRINIVAS other: Former Director other: Former Director
Common Stock 419,700 $2.13 $893,961 Sale
WARD SHANE officer: SVP and General Counsel officer: SVP and General Counsel
Common Stock 776 $2.55 $1,979 Sale
WESTBERG PAUL officer: SVP and Chief Business Officer officer: SVP and Chief Business..
Common Stock 1,326 $2.55 $3,381 Sale
HISLOP COLIN officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 667 $2.55 $1,701 Sale
BRUMM JOSHUA T officer: COO and CFO officer: COO and CFO
Common Stock 1,326 $2.55 $3,381 Sale
PERCEPTIVE ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 1,650,000 $3.21 $5,294,850 Sale
PERCEPTIVE ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 480,000 $3.65 $1,752,480 Sale
WESTBERG PAUL officer: SVP and Chief Business Officer officer: SVP and Chief Business..
Common Stock 711 $16.05 $11,412 Sale
BRUMM JOSHUA T officer: COO and CFO officer: COO and CFO
Common Stock 1,421 $16.05 $22,807 Sale
BRUMM JOSHUA T officer: COO and CFO officer: COO and CFO
Common Stock 1,263 $17.4 $21,976 Sale
SHEPARD JAY other: Former Director other: Former Director
Common Stock 9,114 $17.5 $159,495 Sale
WESTBERG PAUL officer: SVP and Chief Business Officer officer: SVP and Chief Business..
Common Stock 1,316 $19.85 $26,123