Sale
WATANABE TODD FRANKLIN director, officer: See Remarks director, officer: See Remarks
Common Stock 13,783 $8.74 $120,436 Sale
MATSUDA MASARU officer: See Remark officer: See Remark
Common Stock 5,016 $8.74 $43,830 Sale
BURNETT PATRICK officer: See Remarks officer: See Remarks
Common Stock 9,555 $8.74 $83,492 Sale
MATSUDA MASARU officer: See Remark officer: See Remark
Common Stock 3,760 $11.12 $41,815 Sale
BURNETT PATRICK officer: See Remarks officer: See Remarks
Common Stock 4,782 $11.12 $53,181 Sale
WATANABE TODD FRANKLIN director, officer: See Remarks director, officer: See Remarks
Common Stock 14,903 $11.12 $165,736 Sale
MOORE MATTHEW RICHARD officer: SVP and Chief Business Offi.. officer: SVP and Chief Business..
Common Stock 3,468 $11.12 $38,568 Purchase
HERON PATRICK J director director
Common Stock 21,052 $9.5 $199,994 Sale
WATANABE TODD FRANKLIN director, officer: See Remarks director, officer: See Remarks
Common Stock 2,465 $10.6 $26,129 Sale
BURNETT PATRICK officer: See Remarks officer: See Remarks
Common Stock 1,325 $3.54 $4,692 Option
WATANABE TODD FRANKLIN director, officer: See Remarks director, officer: See Remarks
Common Stock 59,525 $1.68 $100,062 Option
WATANABE TODD FRANKLIN director, officer: See Remarks director, officer: See Remarks
Stock Option (right to buy) 59,525 $1.68 $100,062 Sale
MATSUDA MASARU officer: See Remark officer: See Remark
Common Stock 1,850 $1.98 $3,661 Purchase
FRAZIER LIFE SCIENCES VIII, L.P. 10 percent owner 10 percent owner
Common Stock 80,000 $2.5 $200,000 Sale
BURNETT PATRICK officer: See Remarks officer: See Remarks
Common Stock 300 $7.05 $2,115 Sale
BURNETT PATRICK officer: See Remarks officer: See Remarks
Common Stock 1,305 $7.04 $9,187 Sale
MATSUDA MASARU officer: See Remark officer: See Remark
Common Stock 1,830 $7.8 $14,278 Option
WELGUS HOWARD G. director director
Common Stock 8,500 $1.68 $14,289 Sale
WELGUS HOWARD G. director director
Common Stock 8,500 $13.97 $118,728 Option
WELGUS HOWARD G. director director
Stock Option (right to buy) 8,500 $1.68 $14,289 Option
WELGUS HOWARD G. director director
Common Stock 8,500 $1.68 $14,289 Sale
WELGUS HOWARD G. director director
Common Stock 8,500 $12.01 $102,085 Option
WELGUS HOWARD G. director director
Stock Option (right to buy) 8,500 $1.68 $14,289 Sale
WATANABE TODD FRANKLIN director, officer: See Remarks director, officer: See Remarks
Common Stock 2,435 $15.26 $37,168 Sale
BURROWS SCOTT L officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 291 $15.26 $4,442 Sale
LOCK KENNETH A. officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 831 $15.26 $12,684 Sale
TURNEY PATRICIA A. officer: SVP, Operations officer: SVP, Operations
Common Stock 831 $15.26 $12,684 Sale
BURNETT PATRICK officer: See Remarks officer: See Remarks
Common Stock 851 $15.26 $12,989 Sale
OSBORNE DAVID W officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 690 $15.26 $10,531 Sale
WATANABE TODD FRANKLIN director, officer: Reporting Person.. director, officer: Reporting Pe..
Common Stock 69 $16.52 $1,140 Sale
WATANABE TODD FRANKLIN director, officer: Reporting Person.. director, officer: Reporting Pe..
Common Stock 5,403 $15.82 $85,465 Sale
TURNEY PATRICIA A. officer: SVP, Operations officer: SVP, Operations
Common Stock 18 $16.52 $297 Sale
TURNEY PATRICIA A. officer: SVP, Operations officer: SVP, Operations
Common Stock 1,414 $15.82 $22,367 Sale
OSBORNE DAVID W officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 15 $16.52 $248 Sale
OSBORNE DAVID W officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 1,198 $15.82 $18,951 Sale
LOCK KENNETH A. officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 18 $16.52 $297 Sale
LOCK KENNETH A. officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 1,414 $15.82 $22,367 Sale
BURROWS SCOTT L officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 18 $16.52 $297 Sale
BURROWS SCOTT L officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 1,416 $15.82 $22,398 Sale
MOORE MATTHEW RICHARD officer: Reporting Person's title: S.. officer: Reporting Person's tit..
Common Stock 21 $16.52 $347 Sale
MOORE MATTHEW RICHARD officer: Reporting Person's title: S.. officer: Reporting Person's tit..
Common Stock 1,589 $15.82 $25,135 Sale
BURNETT PATRICK officer: Reporting Person's title: Senior .. officer: Reporting Person's tit..
Common Stock 23 $16.52 $380 Sale
BURNETT PATRICK officer: Reporting Person's title: Senior .. officer: Reporting Person's tit..
Common Stock 1,728 $15.82 $27,334 Sale
MATSUDA MASARU officer: Reporting Person's title: Senior V.. officer: Reporting Person's tit..
Common Stock 1,416 $15.82 $22,398 Sale
MATSUDA MASARU officer: Reporting Person's title: Senior V.. officer: Reporting Person's tit..
Common Stock 18 $16.52 $297 Sale
WATANABE TODD FRANKLIN director, officer: Reporting Person.. director, officer: Reporting Pe..
Common Stock 2,343 $16.17 $37,877 Sale
TURNEY PATRICIA A. officer: SVP, Operations officer: SVP, Operations
Common Stock 936 $16.17 $15,131 Sale
OSBORNE DAVID W officer: Chief Technical Officer officer: Chief Technical Officer
Common Stock 792 $16.17 $12,803 Sale
LOCK KENNETH A. officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 936 $16.17 $15,131 Sale
BURROWS SCOTT L officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 416 $16.17 $6,725 
