Sale
WISNIEWSKI RAPHAEL director, 10 percent owner director, 10 percent owner
Common Stock 135,261 $31.54 $4,266,402 Sale
ANDERA PARTNERS 10 percent owner 10 percent owner
Common Stock 164,739 $31.51 $5,191,420 Sale
WISNIEWSKI RAPHAEL director, 10 percent owner director, 10 percent owner
Common Stock 164,739 $31.51 $5,191,420 Option
COHEN RAYMOND W director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 10,000 $1.63 $16,300 Option
COHEN RAYMOND W director, officer: Chief Executive Officer director, officer: Chief Execut..
Stock Option (Right to Buy) 10,000 $1.63 $16,300 Sale
COHEN RAYMOND W director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 10,000 $1.63 $16,300 Sale
SAMA RINDA officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 5,000 $27.42 $137,105 Sale
DEAREN DANNY L. officer: See Remarks officer: See Remarks
Common Stock 30,000 $26.07 $782,100 Sale
SAMA RINDA officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 5,000 $23.92 $119,620 Sale
WOOCK JOHN officer: Chief Marketing Officer officer: Chief Marketing Officer
Common Stock 15,000 $23.82 $357,285 Sale
ANDERA PARTNERS 10 percent owner 10 percent owner
Common Stock 300,000 $20.74 $6,220,500 Sale
DEAREN DANNY L. officer: See Remarks officer: See Remarks
Common Stock 30,000 $21.61 $648,240 Sale
WISNIEWSKI RAPHAEL director, 10 percent owner director, 10 percent owner
Common Stock 300,000 $20.74 $6,220,500 Sale
COHEN RAYMOND W director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 75,000 $20.74 $1,555,125 Sale
DEAREN DANNY L. officer: See Remarks officer: See Remarks
Common Stock 30,000 $20.74 $622,050 Sale
SAMA RINDA officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 5,000 $23 $115,010 Sale
SAMA RINDA officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 5,000 $26.62 $133,075 Purchase
COHEN RAYMOND W director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 3,500 $30.41 $106,439 Option
NOBLETT KAREN officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (Right to Buy) 14,404 $1.31 $18,797 Option
NOBLETT KAREN officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 14,404 $1.31 $18,797 Sale
WILLIAMSON MICHAEL V. officer: SVP, General Counsel officer: SVP, General Counsel
Common Stock 2,944 $43 $126,592 Sale
WILLIAMSON MICHAEL V. officer: SVP, General Counsel officer: SVP, General Counsel
Common Stock 2,056 $42.51 $87,396 Option
PARDO GEOFF other: Former 10% Owner other: Former 10% Owner
Common Stock 4,167 $14.8 $61,672 Option
PARDO GEOFF other: Former 10% Owner other: Former 10% Owner
Stock Option (Right to Buy) 4,167 $14.8 $61,672 Sale
PARDO GEOFF other: Former 10% Owner other: Former 10% Owner
Common Stock 1,695 $38.12 $64,607 Purchase
SNYDERMAN NANCY LYNN MD director director
Common Stock 2,000 $37.12 $74,240 Sale
WILLIAMSON MICHAEL V. officer: SVP, General Counsel officer: SVP, General Counsel
Common Stock 5,000 $36.01 $180,060 Sale
SAMA RINDA officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 13,345 $28.03 $373,994 Option
SAMA RINDA officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 13,345 $1.23 $16,414 Option
SAMA RINDA officer: Chief Operating Officer officer: Chief Operating Officer
Stock Options (Right to buy) 11,545 $1.27 $14,697 Purchase
ANDERA PARTNERS 10 percent owner 10 percent owner
Common Stock 866,666 $15 $12,999,990 Purchase
GILDE HEALTHCARE HOLDING B.V. other: Former 10% Owner other: Former 10% Owner
Common Stock 866,666 $15 $12,999,990 Purchase
PARDO GEOFF other: Former 10% Owner other: Former 10% Owner
Common Stock 866,666 $15 $12,999,990 Purchase
LONGITUDE CAPITAL PARTNERS III, LLC 10 percent owner 10 percent owner
Common Stock 533,333 $15 $7,999,995 Purchase
WISNIEWSKI RAPHAEL director, 10 percent owner director, 10 percent owner
Common Stock 866,666 $15 $12,999,990 Purchase
TAMMENOMS BAKKER JULIET director director
Common Stock 533,333 $15 $7,999,995 Purchase
CORMORANT ASSET MANAGEMENT, LP 10 percent owner 10 percent owner
Common Stock 133,333 $15 $1,999,995