Option
OYLER JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
Share Option (Right to Buy) 1,300,000 $0.5 $650,000 Option
OYLER JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
Ordinary Shares 1,300,000 $0.5 $650,000 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 1,300 $188.79 $245,428 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 1,833 $190.57 $349,311 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 993 $191.78 $190,435 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 1,374 $192.61 $264,642 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 725 $194.01 $140,655 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 300 $195.67 $58,700 Option
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 41,760 $6.5 $271,440 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 2,600 $183.6 $477,368 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 7,063 $184.83 $1,305,475 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 9,956 $185.73 $1,849,168 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 9,266 $186.99 $1,732,649 Option
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
Share Option (Right to Buy) 542,880 $0.5 $271,440 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 6,350 $187.6 $1,191,279 Sale
BAKER BROS. ADVISORS LP director director
American Depositary Shares 83,036 $186.5 $15,486,214 Sale
BAKER BROS. ADVISORS LP director director
American Depositary Shares 33,943 $208.01 $7,060,619 Sale
BAKER BROS. ADVISORS LP director director
American Depositary Shares 916,964 $186.5 $171,013,786 Sale
BAKER BROS. ADVISORS LP director director
American Depositary Shares 3,074 $208.01 $639,435 Sale
WU XIAOBIN officer: President, COO & GM China officer: President, COO & GM Ch..
RMB Shares 0 N/A N/A Sale
HHLR ADVISORS, LTD. 10 percent owner 10 percent owner
Ordinary Shares 17,842,500 $200 $3,568,500,000 Option
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 38,461 $6.5 $249,997 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 4,425 $187.16 $828,174 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 300 $187.61 $56,282 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 5,875 $187.98 $1,104,388 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 400 $188.55 $75,419 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 2,700 $189.17 $510,748 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 200 $189.76 $37,952 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 6,187 $190.32 $1,177,516 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 700 $191.05 $133,732 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 12,293 $191.22 $2,350,704 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 407 $191.81 $78,066 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 1,014 $187.15 $189,765 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 1,186 $188.08 $223,061 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 600 $189.03 $113,417 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 1,475 $190.31 $280,703 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 2,725 $191.24 $521,118 Option
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
Share Option (Right to Buy) 499,993 $0.5 $249,997 Sale
WANG XIAODONG director, other: Chair, Scientific Advisory .. director, other: Chair, Scienti..
American Depositary Shares 7,864 $191.92 $1,509,290 Sale
OYLER JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
American Depositary Shares 2,535 $229.25 $581,139 Sale
OYLER JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
American Depositary Shares 2,827 $230.05 $650,351 Sale
OYLER JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
American Depositary Shares 1,565 $229.25 $358,770 Sale
OYLER JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
American Depositary Shares 371 $231.05 $85,718 Sale
OYLER JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
American Depositary Shares 62 $233 $14,446 Sale
OYLER JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
American Depositary Shares 694 $234.27 $162,585 Sale
OYLER JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
American Depositary Shares 1,747 $230.05 $401,897 Sale
OYLER JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
American Depositary Shares 229 $231.05 $52,909 Sale
OYLER JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
American Depositary Shares 38 $233 $8,854 Sale
OYLER JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
American Depositary Shares 428 $234.27 $100,269 Sale
OYLER JOHN director, officer: Chief Executive Officer director, officer: Chief Execut..
American Depositary Shares 2,059 $235.41 $484,715 
