BeiGene, Ltd.
Substituted pyrazolo[1,5-a]pyrimidines as Bruton's tyrosine kinase modulators

Abstract:

The invention is fused heterocyclic compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain fused heterocyclic compounds that can be useful for inhibiting protein kinase, including Bruton's tyrosine kinase (Btk), and for treating disorders mediated thereby. ##STR00001##