| Utility: DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE Filling date: 26 Sep 2025 Issue date: 8 Sep 2022 | 24 Jul 2020 | 8 Sep 2022 |
| Utility: TRICYCLIC COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF Filling date: 26 Sep 2025 Issue date: 25 Aug 2022 | 17 Jul 2020 | 25 Aug 2022 |
| Utility: PYRROLO[2,3-b]PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF Filling date: 26 Sep 2025 Issue date: 25 Aug 2022 | 3 Jul 2020 | 25 Aug 2022 |
| Utility: CYCLIC DINUCLEOTIDES AS STING AGONISTS Filling date: 26 Sep 2025 Issue date: 11 Aug 2022 | 24 Jul 2020 | 11 Aug 2022 |
| Utility: PARP INHIBITOR PELLET PREPARATION AND PREPARATION PROCESS THEREFOR Filling date: 26 Sep 2025 Issue date: 28 Jul 2022 | 29 May 2020 | 28 Jul 2022 |
| Utility: AMIDE-SUBSTITUTED IMIDAZO COMPOUNDS AS SELECTIVE INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASES Filling date: 26 Sep 2025 Issue date: 21 Jul 2022 | 21 May 2020 | 21 Jul 2022 |
| Utility: Interoperable platform for reducing redundancy in medical database management Filling date: 26 Sep 2025 Issue date: 19 Jul 2022 | 13 Jul 2021 | 19 Jul 2022 |
| Utility: BTK inhibitors with improved dual selectivity Filling date: 26 Sep 2025 Issue date: 5 Jul 2022 | 12 Aug 2018 | 5 Jul 2022 |
| Utility: ANTI-TIGIT ANTIBODIES AND THEIR USE AS THERAPEUTICS AND DIAGNOSTICS Filling date: 26 Sep 2025 Issue date: 19 May 2022 | 24 Nov 2021 | 19 May 2022 |
| Utility: ANTI-TIM-3 ANTIBODIES AND USE THEREOF Filling date: 26 Sep 2025 Issue date: 5 May 2022 | 15 Nov 2021 | 5 May 2022 |
| Utility: IMIDAZO[2,1-F][1,2,4]TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST Filling date: 26 Sep 2025 Issue date: 21 Apr 2022 | 6 Feb 2020 | 21 Apr 2022 |
| Utility: STABLE SOLID DISPERSION OF A B-RAF KINASE DIMER INHIBITOR, METHODS OF PREPARATION, AND USES THEREFOR Filling date: 26 Sep 2025 Issue date: 7 Apr 2022 | 23 Jan 2020 | 7 Apr 2022 |
| Utility: IMIDAZO[1,5-a]PYRAZINE DERIVATIVES AS PI3K DELTA INHIBITORS Filling date: 26 Sep 2025 Issue date: 31 Mar 2022 | 8 Jul 2021 | 31 Mar 2022 |
| Utility: IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3KDELTA INHIBITORS Filling date: 26 Sep 2025 Issue date: 17 Mar 2022 | 23 Nov 2021 | 17 Mar 2022 |
| Utility: Imidazo[1,5-a]pyrazine derivatives as PI3Kdelta inhibitors Filling date: 26 Sep 2025 Issue date: 11 Jan 2022 | 7 Sep 2018 | 11 Jan 2022 |
| Utility: Anti-TIGIT antibodies and their use as therapeutics and diagnostics Filling date: 26 Sep 2025 Issue date: 4 Jan 2022 | 29 Dec 2018 | 4 Jan 2022 |
| Utility: Treatment cancers using a combination comprising PARP inhibitors Filling date: 26 Sep 2025 Issue date: 21 Dec 2021 | 27 Sep 2017 | 21 Dec 2021 |
| Utility: Anti-Tim-3 antibodies and use thereof Filling date: 26 Sep 2025 Issue date: 21 Dec 2021 | 25 Aug 2017 | 21 Dec 2021 |
| Utility: CRYSTALLINE FORMS OF (S)-7-(1-(BUT-2-YNOYL)PIPERIDIN-4-YL)-2-(4-PHENOXYPHENYL)-4,5,6,7-TETRAHY- DROPYRAZOLO[1,5-a]PYRIMIDINE-3-CARBOXAMIDE, PREPARATION, AND USES THEREOF Filling date: 26 Sep 2025 Issue date: 28 Oct 2021 | 25 Jan 2018 | 28 Oct 2021 |
| Utility: Imidazo[1,5-a]pyrazine derivatives as PI3K .delta. inhibitors Filling date: 26 Sep 2025 Issue date: 5 Oct 2021 | 7 Dec 2017 | 5 Oct 2021 |
| Utility: PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES AS A2A RECEPTOR ANTAGONIST Filling date: 26 Sep 2025 Issue date: 30 Sep 2021 | 22 Jul 2019 | 30 Sep 2021 |
| Utility: TREATMENT CANCERS USING A COMBINATION COMPRISING BTK INHIBITORS Filling date: 26 Sep 2025 Issue date: 9 Sep 2021 | 18 Aug 2017 | 9 Sep 2021 |
| Utility: BCL-2 INHIBITORS Filling date: 26 Sep 2025 Issue date: 2 Sep 2021 | 29 Apr 2019 | 2 Sep 2021 |
| Utility: COMBINATION OF A PD-1 ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER Filling date: 26 Sep 2025 Issue date: 29 Jul 2021 | 16 Nov 2020 | 29 Jul 2021 |
| Utility: ANTI-OX40 ANTIBODIES AND METHODS OF USE Filling date: 26 Sep 2025 Issue date: 15 Jul 2021 | 22 May 2019 | 15 Jul 2021 |
| Utility: MAINTENANCE THERAPY OF A PARP INHIBITOR IN TREATING GASTRIC CANCER Filling date: 26 Sep 2025 Issue date: 8 Jul 2021 | 31 May 2019 | 8 Jul 2021 |
| Utility: PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES AS A2A RECEPTOR ANTAGONIST Filling date: 26 Sep 2025 Issue date: 1 Jul 2021 | 8 Apr 2019 | 1 Jul 2021 |
| Utility: IMMUNOTHERAPY FOR HEPATOCELLULAR CARCINOMA Filling date: 26 Sep 2025 Issue date: 20 May 2021 | 26 Jun 2018 | 20 May 2021 |
| Utility: IMMUNOMONOTHERAPY FOR UROTHELIAL CARCINOMA Filling date: 26 Sep 2025 Issue date: 11 Feb 2021 | 8 Feb 2019 | 11 Feb 2021 |
| Utility: Crystalline forms of salts of fused penta-cyclic dihydrodiazepinocarbazolones, and uses thereof Filling date: 26 Sep 2025 Issue date: 26 Jan 2021 | 27 Feb 2018 | 26 Jan 2021 |
| Utility: 5 or 8-substituted imidazo [1,5-a] pyridines as selective inhibitors of indoleamine and/or tryptophane 2,3-dioxygenases Filling date: 26 Sep 2025 Issue date: 5 Jan 2021 | 23 Sep 2017 | 5 Jan 2021 |
| Utility: Combination of a PD-1 antagonist and a RAF inhibitor for treating cancer Filling date: 26 Sep 2025 Issue date: 15 Dec 2020 | 14 Jun 2017 | 15 Dec 2020 |
| Utility: ANTI-TIGIT ANTIBODIES AND THEIR USE AS THERAPEUTICS AND DIAGNOSTICS Filling date: 26 Sep 2025 Issue date: 22 Oct 2020 | 29 Dec 2018 | 22 Oct 2020 |
| Utility: NOVEL BENZOIMIDAZOLES AS SELECTIVE INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASES Filling date: 26 Sep 2025 Issue date: 8 Oct 2020 | 24 Nov 2018 | 8 Oct 2020 |
| Utility: ANTI-PD-L1 ANTIBODIES AND THEIR USE AS THERAPEUTICS AND DIAGNOSTICS Filling date: 26 Sep 2025 Issue date: 10 Sep 2020 | 5 Dec 2019 | 10 Sep 2020 |
| Utility: IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3KDELTA INHIBITORS Filling date: 26 Sep 2025 Issue date: 2 Jul 2020 | 7 Sep 2018 | 2 Jul 2020 |
| Utility: BTK INHIBITORS WITH IMPROVED DUAL SELECTIVITY Filling date: 26 Sep 2025 Issue date: 11 Jun 2020 | 12 Aug 2018 | 11 Jun 2020 |
| Utility: TREATMENT OF CANCERS USING A COMBINATION COMPRISING PARP INHIBITORS, TEMOZOLOMIDE AND/OR RADIATION THERAPY Filling date: 26 Sep 2025 Issue date: 21 May 2020 | 17 Jul 2018 | 21 May 2020 |
| Utility: CRYSTALLINE FORMS OF SALTS OF FUSED TERA OR PENTA-CYCLIC DIHYDRODIAZEPINOCARAZOLONES, AND USES THEREOF Filling date: 26 Sep 2025 Issue date: 21 May 2020 | 27 Feb 2018 | 21 May 2020 |
| Utility: 5 or 8-substituted imidazo[1,5-a]pyridines as indoleamine and/or tryptophane 2,3-dioxygenases Filling date: 26 Sep 2025 Issue date: 12 May 2020 | 27 Mar 2019 | 12 May 2020 |
| Utility: COMBINATION OF A PD-1 ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER Filling date: 26 Sep 2025 Issue date: 5 Mar 2020 | 14 Jun 2017 | 5 Mar 2020 |
| Utility: Fused tricyclic compounds as Raf kinase inhibitors Filling date: 26 Sep 2025 Issue date: 3 Mar 2020 | 29 Jan 2018 | 3 Mar 2020 |
| Utility: Substituted pyrazolo[1,5-a]pyrimidines as Bruton's tyrosine kinase modulators Filling date: 26 Sep 2025 Issue date: 25 Feb 2020 | 3 May 2018 | 25 Feb 2020 |
| Utility: Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors Filling date: 26 Sep 2025 Issue date: 18 Feb 2020 | 9 Jan 2019 | 18 Feb 2020 |
| Utility: TREATMENT CANCERS USING A COMBINATION COMPRISING PARP INHIBITORS Filling date: 26 Sep 2025 Issue date: 30 Jan 2020 | 27 Sep 2017 | 30 Jan 2020 |
| Utility: Anti-PD-L1 antibodies and their use as therapeutics and diagnostics Filling date: 26 Sep 2025 Issue date: 28 Jan 2020 | 1 Jul 2015 | 28 Jan 2020 |
| Utility: NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1,5-a] PYRIDINES AS SELECTIVE INHIBITORS OF INDOLEAMINE AND/OR TRYPTOPHANE 2,3-DIOXYGENASES Filling date: 26 Sep 2025 Issue date: 23 Jan 2020 | 23 Sep 2017 | 23 Jan 2020 |
| Utility: Anti-PD1 antibodies and their use as therapeutics and diagnostics Filling date: 26 Sep 2025 Issue date: 31 Dec 2019 | 14 May 2018 | 31 Dec 2019 |
| Utility: Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as PARP inhibitors Filling date: 26 Sep 2025 Issue date: 10 Dec 2019 | 19 Sep 2018 | 10 Dec 2019 |
| Utility: IMIDAZO[1,5-a]PYRAZINE DERIVATIVES AS PI3K DELTA INHIBITORS Filling date: 26 Sep 2025 Issue date: 5 Dec 2019 | 7 Dec 2017 | 5 Dec 2019 |
