Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 95,800 $10.45 $1,001,110 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 35,850 $10.45 $374,453 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 124,525 $10.39 $1,294,313 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 17,700 $10.38 $183,638 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 18,676 $10.38 $193,876 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 17,600 $10.37 $182,582 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 48,334 $10.37 $501,224 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 20,743 $10.37 $215,105 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 37,500 $10.37 $388,913 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 79,475 $10.37 $824,474 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 153,700 $10.38 $1,596,021 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 69,230 $10.38 $718,677 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 73,400 $10.38 $761,965 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 47,396 $10.38 $491,970 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 64,683 $10.38 $671,539 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 27,668 $10.39 $287,415 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 37,430 $10.39 $388,823 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 62,200 $10.38 $645,885 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 85,611 $10.39 $889,413 Sale
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 399,923 $10.42 $4,165,198 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 300 $2.7 $811 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 5,990 $2.84 $16,982 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
Common Stock 1,820 $2.9 $5,278 Purchase
KRIEG ARTHUR M officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 7,224 N/A N/A Purchase
KRIEG ARTHUR M officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 3,578 $6.18 $22,112 Purchase
KRIEG ARTHUR M officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 25,001 N/A N/A Purchase
KRIEG ARTHUR M officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 33,220 N/A N/A Purchase
KRIEG ARTHUR M officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 3,484 $12.15 $42,331 Purchase
KRIEG ARTHUR M officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 10,036 $12.35 $123,945 Option
CHAUDHARY KLEEM officer: Chief Business Officer officer: Chief Business Officer
Common Stock 2,000 $2.62 $5,240 Option
CHAUDHARY KLEEM officer: Chief Business Officer officer: Chief Business Officer
Stock Option (right to buy) 2,000 $2.62 $5,240 Purchase
KRIEG ARTHUR M officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 1,701 $13.05 $22,198 Purchase
KRIEG ARTHUR M officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 500 $13.09 $6,545 Option
CHAUDHARY KLEEM officer: Chief Business Officer officer: Chief Business Officer
Common Stock 2,000 $2.62 $5,240 Option
CHAUDHARY KLEEM officer: Chief Business Officer officer: Chief Business Officer
Stock Option (right to buy) 2,000 $2.62 $5,240 Purchase
KRIEG ARTHUR M officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 443 $14.16 $6,273 Purchase
KRIEG ARTHUR M officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 5,103 $14.64 $74,708 Option
CHAUDHARY KLEEM officer: Chief Business Officer officer: Chief Business Officer
Common Stock 4,000 $2.62 $10,480 Option
CHAUDHARY KLEEM officer: Chief Business Officer officer: Chief Business Officer
Stock Option (right to buy) 4,000 $2.62 $10,480 Purchase
KRIEG ARTHUR M officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 4,805 $14.62 $70,249 Purchase
KRIEG ARTHUR M officer: Chief Scientific Officer officer: Chief Scientific Officer
Common Stock 42 $14.49 $609 Purchase
POWELL MICHAEL director, 10 percent owner director, 10 percent owner
Common Stock 133,333 $15 $1,999,995 Purchase
VENBIO GLOBAL STRATEGIC FUND II L.P. 10 percent owner 10 percent owner
Common Stock 200,000 $15 $3,000,000 Purchase
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
COMMON STOCK 500,000 $15 $7,500,000