Purchase
GURNET HOLDING CO 10 percent owner 10 percent owner
Common Stock 5,051,463 $12.5 $63,143,288 Purchase
GURNET HOLDING CO 10 percent owner 10 percent owner
Common Stock 31,578,042 $12.5 $394,725,525 Option
STAPLE PETER D director, officer: President & CEO director, officer: President & ..
Common Stock 42,859 $2.22 $95,233 Option
STAPLE PETER D director, officer: President & CEO director, officer: President & ..
Employee Stock Option (Right to Buy) 42,859 $2.22 $95,233 Sale
PERCEPTIVE ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 2,850,000 $12.52 $35,667,750 Sale
PERCEPTIVE ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 782,447 $12.51 $9,788,412 Sale
STAPLE PETER D director, officer: President & CEO director, officer: President & ..
Common Stock 37,021 $8.99 $332,634 Option
STAPLE PETER D director, officer: President & CEO director, officer: President & ..
Common Stock 7,813 N/A N/A Option
STAPLE PETER D director, officer: President & CEO director, officer: President & ..
Restricted Stock Units (RSU) 7,813 N/A N/A Sale
SINGH PARMINDER officer: CTO & Vice President, R&D officer: CTO & Vice President, ..
Common Stock 3,133 $9.01 $28,225 Option
SINGH PARMINDER officer: CTO & Vice President, R&D officer: CTO & Vice President, ..
Common Stock 9,063 N/A N/A Option
SINGH PARMINDER officer: CTO & Vice President, R&D officer: CTO & Vice President, ..
Restricted Stock Units (RSU) 9,063 N/A N/A Sale
SWEEMER TIMOTHY D officer: Chief Accounting Officer officer: Chief Accounting Officer
Common Stock 346 $9.01 $3,117 Option
SWEEMER TIMOTHY D officer: Chief Accounting Officer officer: Chief Accounting Officer
Common Stock 1,250 N/A N/A Option
SWEEMER TIMOTHY D officer: Chief Accounting Officer officer: Chief Accounting Officer
Restricted Stock Units (RSU) 1,250 N/A N/A Option
SARRET JOSEPH J. officer: Chief Business Officer officer: Chief Business Officer
Common Stock 10,313 N/A N/A Option
SARRET JOSEPH J. officer: Chief Business Officer officer: Chief Business Officer
Restricted Stock Units (RSU) 10,313 N/A N/A Sale
SARRET JOSEPH J. officer: Chief Business Officer officer: Chief Business Officer
Common Stock 3,565 $9.01 $32,117 Sale
BREUIL ROBERT S officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 972 $9.01 $8,757 Option
BREUIL ROBERT S officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 2,813 N/A N/A Option
BREUIL ROBERT S officer: Chief Financial Officer officer: Chief Financial Officer
Restricted Stock Units (RSU) 2,813 N/A N/A Option
SARRET JOSEPH J. officer: Chief Business Officer officer: Chief Business Officer
Common Stock 10,313 N/A N/A Sale
STAPLE PETER D director, officer: President & CEO director, officer: President & ..
Common Stock 39,320 $8.66 $340,590 Option
THOMAS ROBERT director director
Common Stock 35,608 $2.12 $75,525 Sale
THOMAS ROBERT director director
Common Stock 35,608 $2.12 $75,525 Option
THOMAS ROBERT director director
Director Stock Option (Right to Buy) 35,608 $2.12 $75,525 Option
STAPLE PETER D director, officer: President & CEO director, officer: President & ..
Common Stock 190,730 $2.12 $404,538 Option
STAPLE PETER D director, officer: President & CEO director, officer: President & ..
Employee Stock Option (Right to Buy) 190,730 $2.12 $404,538 Option
STAPLE PETER D director, officer: President & CEO director, officer: President & ..
Common Stock 23,586 $2.12 $50,026 Option
STAPLE PETER D director, officer: President & CEO director, officer: President & ..
Employee Stock Option (Right to Buy) 23,586 $2.12 $50,026 Purchase
PERCEPTIVE ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 310,000 $12.8 $3,968,000 Purchase
PERCEPTIVE ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 149,650 $12.24 $1,831,716 Purchase
PERCEPTIVE ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 50,350 $11.83 $595,641 Sale
BROADFIN HEALTHCARE MASTER FUND LTD 10 percent owner 10 percent owner
Common Stock 199,600 $10.97 $2,189,213 Sale
BROADFIN HEALTHCARE MASTER FUND LTD 10 percent owner 10 percent owner
Common Stock 300,400 $10.96 $3,292,384 Sale
BROADFIN HEALTHCARE MASTER FUND LTD 10 percent owner 10 percent owner
Common Stock 150,000 $11.05 $1,657,500 Sale
BROADFIN HEALTHCARE MASTER FUND LTD 10 percent owner 10 percent owner
Common Stock 218,100 $11.01 $2,401,063 Option
STAPLE PETER D director, officer: President & CEO director, officer: President & ..
Common Stock 50,000 $2.12 $106,050 Option
STAPLE PETER D director, officer: President & CEO director, officer: President & ..
Employee Stock Option (Right to Buy) 50,000 $2.12 $106,050 Sale
SINGH PARMINDER officer: CTO & Vice President, R&D officer: CTO & Vice President, ..
Common Stock 22,822 $7.61 $173,561 Option
GARDNER PHYLLIS director director
Director Stock Option (Right to Buy) 33,064 $2.12 $70,129 Option
GARDNER PHYLLIS director director
Common Stock 33,064 $2.12 $70,129 Sale
SINGH PARMINDER officer: CTO & Vice President, R&D officer: CTO & Vice President, ..
Common Stock 7,593 $7.53 $57,137 Sale
SWEEMER TIMOTHY D officer: Chief Accounting Officer officer: Chief Accounting Officer
Common Stock 12,012 $7.62 $91,531 Option
SINGH PARMINDER officer: CTO & Vice President, R&D officer: CTO & Vice President, ..
Common Stock 58,415 $2.17 $126,877 Sale
SINGH PARMINDER officer: CTO & Vice President, R&D officer: CTO & Vice President, ..
Common Stock 32,000 $7.61 $243,616 Option
SINGH PARMINDER officer: CTO & Vice President, R&D officer: CTO & Vice President, ..
Employee Stock Option (Right to Buy) 43,564 $2.22 $96,799 Sale
SWEEMER TIMOTHY D officer: Chief Accounting Officer officer: Chief Accounting Officer
Common Stock 15,488 $7.82 $121,163 Option
SWEEMER TIMOTHY D officer: Chief Accounting Officer officer: Chief Accounting Officer
Common Stock 54,949 $2.17 $119,349 Option
SWEEMER TIMOTHY D officer: Chief Accounting Officer officer: Chief Accounting Officer
Employee Stock Option (Right to Buy) 37,623 $2.22 $83,598