Purchase
JONES WILLIAM BENTON officer: See Remarks officer: See Remarks
Common Stock 20,000 $1.73 $34,620 Purchase
JONES WILLIAM BENTON officer: See Remarks officer: See Remarks
Warrant (Right to Buy) 19,357 $3.5 $67,750 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 577,634 $1.73 $999,884 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Warrant (Right to Buy) 559,073 $3.5 $1,956,756 Purchase
THOMPSON PETER A. director, 10 percent owner: director, 10 percent owner:
Pre-Funded Warrants (right to buy) 1,444,085 N/A N/A Purchase
THOMPSON PETER A. director, 10 percent owner: director, 10 percent owner:
Common Warrants (right to buy) 1,397,684 $3.5 $4,891,894 Purchase
ORBIMED ADVISORS LLC director, 10 percent owner: director, 10 percent owner:
Pre-Funded Warrants (right to buy) 1,444,085 N/A N/A Purchase
ORBIMED ADVISORS LLC director, 10 percent owner: director, 10 percent owner:
Common Warrants (right to buy) 1,397,684 $3.5 $4,891,894 Purchase
GRAIS LINDA director director
Common Stock 10,000 $2.45 $24,500 Purchase
JONES WILLIAM BENTON officer: See Remarks officer: See Remarks
Common Stock 20,000 $0.79 $15,800 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 10,000 $0.78 $7,810 Purchase
LEA LEIV officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 4,000 $0.84 $3,364 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 50,000 $0.74 $37,000 Purchase
LEA LEIV officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 30,000 $0.74 $22,290 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 25,000 $0.76 $19,075 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 5,000 $0.82 $4,075 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 2,700 $0.82 $2,214 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 12,300 $0.81 $9,963 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 5,000 $1 $4,985 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 5,000 $1.03 $5,150 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 890 $1.01 $899 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 170 $0.97 $165 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 4,830 $0.98 $4,733 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 15,000 $1.64 $24,540 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 5,000 $1.59 $7,950 Purchase
LEA LEIV officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 13,878 $1.65 $22,899 Purchase
LEA LEIV officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 35,160 $1.54 $54,146 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 25,000 $1.47 $36,650 Sale
ECOR1 CAPITAL, LLC 10 percent owner 10 percent owner
Common Stock 2,000,000 $4.96 $9,928,000 Sale
ECOR1 CAPITAL, LLC 10 percent owner 10 percent owner
Common Stock 3,000,000 $5.04 $15,132,000 Sale
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Common Stock, $0.0001 par value 1,109,644 $6.09 $6,757,732 Sale
THOMPSON PETER A. director, 10 percent owner director, 10 percent owner
Common Stock, $0.0001 par value 1,109,644 $6.09 $6,757,732 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 10,000 $1.93 $19,250 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 35,714 $2.8 $99,999 Purchase
THOMPSON PETER A. director, 10 percent owner director, 10 percent owner
Common Stock, $0.0001 par value 1,285,714 $3.5 $4,499,999 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 100,000 $3.5 $350,000 Purchase
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Common Stock, $0.0001 par value 1,285,714 $3.5 $4,499,999 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
COMMON STOCK 741,440 $5.38 $3,985,240 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
COMMON STOCK 796,622 $5.25 $4,183,062 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 14,736 $3 $44,237 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock 272 $2.9 $789 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock, $0.0001 par value 2,500 $3.54 $8,850 Purchase
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Common Stock, $0.0001 par value 142,656 $3.51 $500,723 Purchase
THOMPSON PETER A. director, 10 percent owner director, 10 percent owner
Common Stock, $0.0001 par value 142,656 $3.51 $500,723 Purchase
MILLER RICHARD A MD director, officer: President and CEO director, officer: President an..
Common Stock, $0.0001 par value 5,000 $3.58 $17,875 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
COMMON STOCK 1,400,000 $4 $5,600,000 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
COMMON STOCK 53,240 $5.01 $266,732 Sale
NOVO HOLDINGS A/S 10 percent owner 10 percent owner
COMMON STOCK 39,716 $5.32 $211,130 Purchase
THOMPSON PETER A. director, 10 percent owner director, 10 percent owner
Common Stock, $0.0001 par value 59,243 $3.91 $231,640 Purchase
ORBIMED ADVISORS LLC director, 10 percent owner director, 10 percent owner
Common Stock, $0.0001 par value 59,243 $3.91 $231,640