CytomX Therapeutics, Inc.
ANTI-CD166 ANTIBODIES AND USES THEREOF

Abstract:

The present invention provides, among other things, an antibody or antigen-binding polypeptide that binds or is capable of binding CD166, compositions including the same, and uses thereof. In certain embodiments, an anti-CD166 antibody or antigen-binding polypeptide of the present invention binds or is capable of binding all or a portion of an intracellular domain ("ICD") of CD166. The present invention also includes, among other things, a nucleic acid molecule encoding an antibody or antigen-binding polypeptide that binds or is capable of binding CD166. In various embodiments, an anti-CD166 antibody or antigen-binding polypeptide is useful in a method of detecting or treating a condition or disease.