Dicerna Pharmaceuticals, Inc.
DOUBLE-STRANDED NUCLEIC ACID INHIBITOR MOLECULES MODIFIED WITH TM-INCREASING NUCLEOTIDES

Abstract:

Provided herein are double-stranded nucleic acid inhibitor molecules having a sense strand with a stem loop structure and an antisense strand, where the stem portion of the stem loop structure contains one or more T.sub.m-increasing nucleotides. Also provided are methods and compositions for reducing target gene expression and methods and compositions for treating a disease of interest.