| Utility: Extended dicer substrate agents and methods for the specific inhibition of gene expression Filling date: 7 Sep 2025 Issue date: 16 Aug 2022 | 20 Aug 2021 | 16 Aug 2022 |
| Utility: 4'-phosphate analogs and oligonucleotides comprising the same Filling date: 7 Sep 2025 Issue date: 16 Aug 2022 | 1 Sep 2017 | 16 Aug 2022 |
| Utility: Extended dicer substrate agents and methods for the specific inhibition of gene expression Filling date: 7 Sep 2025 Issue date: 9 Aug 2022 | 20 Aug 2021 | 9 Aug 2022 |
| Utility: Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded RNA Filling date: 7 Sep 2025 Issue date: 9 Aug 2022 | 12 Aug 2021 | 9 Aug 2022 |
| Utility: METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF ALPHA-1 ANTITRYPSIN BY DOUBLE-STRANDED RNA Filling date: 7 Sep 2025 Issue date: 21 Jul 2022 | 30 Mar 2022 | 21 Jul 2022 |
| Utility: Compositions comprising reversibly modified oligonucleotides and uses thereof Filling date: 7 Sep 2025 Issue date: 19 Jul 2022 | 23 Aug 2017 | 19 Jul 2022 |
| Utility: Extended dicer substrate agents and methods for the specific inhibition of gene expression Filling date: 7 Sep 2025 Issue date: 14 Jun 2022 | 4 Jun 2021 | 14 Jun 2022 |
| Utility: Therapeutic inhibition of lactate dehydrogenase and agents therefor Filling date: 7 Sep 2025 Issue date: 14 Jun 2022 | 1 Jul 2020 | 14 Jun 2022 |
| Utility: DOUBLE-STRANDED NUCLEIC ACID INHIBITOR MOLECULES WITH SHORTENED SENSE STRANDS Filling date: 7 Sep 2025 Issue date: 9 Jun 2022 | 29 Apr 2020 | 9 Jun 2022 |
| Utility: Process for formulating an anionic agent Filling date: 7 Sep 2025 Issue date: 7 Jun 2022 | 19 Oct 2018 | 7 Jun 2022 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION IN THE CENTRAL NERVOUS SYSTEM Filling date: 7 Sep 2025 Issue date: 2 Jun 2022 | 3 Apr 2020 | 2 Jun 2022 |
| Utility: EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION Filling date: 7 Sep 2025 Issue date: 26 May 2022 | 8 Nov 2021 | 26 May 2022 |
| Utility: COMPOSITIONS AND METHODS FOR THE TREATMENT OF KRAS ASSOCIATED DISEASES OR DISORDERS Filling date: 7 Sep 2025 Issue date: 19 May 2022 | 27 Mar 2020 | 19 May 2022 |
| Utility: Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded RNA Filling date: 7 Sep 2025 Issue date: 26 Apr 2022 | 10 Sep 2021 | 26 Apr 2022 |
| Utility: Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded RNA Filling date: 7 Sep 2025 Issue date: 26 Apr 2022 | 12 Aug 2021 | 26 Apr 2022 |
| Utility: Methods and compositions for inhibiting expression of LDHA Filling date: 7 Sep 2025 Issue date: 29 Mar 2022 | 12 Oct 2018 | 29 Mar 2022 |
| Utility: Methods for treating hepatitis B infection Filling date: 7 Sep 2025 Issue date: 15 Mar 2022 | 12 May 2021 | 15 Mar 2022 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING HMGB1 EXPRESSION Filling date: 7 Sep 2025 Issue date: 10 Mar 2022 | 20 Dec 2019 | 10 Mar 2022 |
| Utility: EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION Filling date: 7 Sep 2025 Issue date: 30 Dec 2021 | 20 Aug 2021 | 30 Dec 2021 |
| Utility: Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded RNA Filling date: 7 Sep 2025 Issue date: 28 Dec 2021 | 1 Jul 2020 | 28 Dec 2021 |
| Utility: EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION Filling date: 7 Sep 2025 Issue date: 16 Dec 2021 | 20 Aug 2021 | 16 Dec 2021 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING ALDH2 EXPRESSION Filling date: 7 Sep 2025 Issue date: 9 Dec 2021 | 15 Jan 2019 | 9 Dec 2021 |
| Utility: AMINE CATIONIC LIPIDS AND USES THEREOF Filling date: 7 Sep 2025 Issue date: 23 Sep 2021 | 8 Jun 2021 | 23 Sep 2021 |
| Utility: EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION Filling date: 7 Sep 2025 Issue date: 23 Sep 2021 | 4 Jun 2021 | 23 Sep 2021 |
| Utility: METHODS FOR TREATING HEPATITIS B INFECTION Filling date: 7 Sep 2025 Issue date: 16 Sep 2021 | 12 May 2021 | 16 Sep 2021 |
| Utility: BETA CATENIN NUCLEIC ACID INHIBITOR MOLECULE Filling date: 7 Sep 2025 Issue date: 5 Aug 2021 | 15 Apr 2021 | 5 Aug 2021 |
| Utility: PCSK9 TARGETING OLIGONUCLEOTIDES FOR TREATING HYPERCHOLESTEROLEMIA AND RELATED CONDITIONS Filling date: 7 Sep 2025 Issue date: 5 Aug 2021 | 1 Apr 2019 | 5 Aug 2021 |
| Utility: METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GLYCOLATE OXIDASE (HAO1) BY DOUBLE-STRANDED RNA Filling date: 7 Sep 2025 Issue date: 29 Jul 2021 | 25 Jan 2021 | 29 Jul 2021 |
| Utility: Methods and compositions for the specific inhibition of transthyretin (TTR) by double stranded RNA Filling date: 7 Sep 2025 Issue date: 20 Jul 2021 | 1 Apr 2020 | 20 Jul 2021 |
| Utility: Methods and compositions for the specific inhibition of glycolate oxidase (HAO1) by double-stranded RNA Filling date: 7 Sep 2025 Issue date: 13 Jul 2021 | 20 Aug 2019 | 13 Jul 2021 |
| Utility: Amine cationic lipids and uses thereof Filling date: 7 Sep 2025 Issue date: 13 Jul 2021 | 29 Nov 2018 | 13 Jul 2021 |
| Utility: Methods for treating hepatitis B infection Filling date: 7 Sep 2025 Issue date: 6 Jul 2021 | 7 Jul 2020 | 6 Jul 2021 |
| Utility: Methods for treating hepatitis B infection Filling date: 7 Sep 2025 Issue date: 6 Jul 2021 | 7 Jul 2020 | 6 Jul 2021 |
| Utility: THERAPEUTIC INHIBITION OF LACTATE DEHYDROGENASE AND AGENTS THEREFOR Filling date: 7 Sep 2025 Issue date: 17 Jun 2021 | 1 Jul 2020 | 17 Jun 2021 |
| Utility: METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF ALPHA-1 ANTITRYPSIN BY DOUBLE-STRANDED RNA Filling date: 7 Sep 2025 Issue date: 17 Jun 2021 | 1 Jul 2020 | 17 Jun 2021 |
| Utility: Beta catenin nucleic acid inhibitor molecule Filling date: 7 Sep 2025 Issue date: 18 May 2021 | 17 Oct 2018 | 18 May 2021 |
| Utility: METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF COMPLEMENT COMPONENT 5(C5) BY DOUBLE-STRANDED RNA Filling date: 7 Sep 2025 Issue date: 13 May 2021 | 17 Dec 2020 | 13 May 2021 |
| Utility: METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF ANTITHROMBIN 3 (AT3) BY DOUBLE-STRANDED RNA Filling date: 7 Sep 2025 Issue date: 1 Apr 2021 | 28 Feb 2020 | 1 Apr 2021 |
| Utility: EXTENDED DICER SUBSTRATE AGENTS AND METHODS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION Filling date: 7 Sep 2025 Issue date: 4 Mar 2021 | 12 Nov 2020 | 4 Mar 2021 |
| Utility: METHODS AND COMPOSITIONS FOR INHIBITING EXPRESSION OF LDHA Filling date: 7 Sep 2025 Issue date: 4 Mar 2021 | 16 Sep 2020 | 4 Mar 2021 |
| Utility: COMPOSITIONS AND METHODS FOR INHIBITING GYS2 EXPRESSION Filling date: 7 Sep 2025 Issue date: 4 Mar 2021 | 15 Feb 2019 | 4 Mar 2021 |
| Utility: COMPOSITIONS AND METHODS FOR THE TREATMENT OF A BETA-CATENIN-ASSOCIATED DISEASE OR DISORDER Filling date: 7 Sep 2025 Issue date: 21 Jan 2021 | 29 Sep 2020 | 21 Jan 2021 |
| Utility: METHODS AND COMPOSITIONS FOR TREATING BILE DUCT PAUCITY-ASSOCIATED CONDITIONS Filling date: 7 Sep 2025 Issue date: 14 Jan 2021 | 15 Feb 2019 | 14 Jan 2021 |
| Utility: Extended dicer substrate agents and methods for the specific inhibition of gene expression Filling date: 7 Sep 2025 Issue date: 22 Dec 2020 | 20 Oct 2014 | 22 Dec 2020 |
| Utility: REDUCING BETA-CATENIN EXPRESSION TO POTENTIATE IMMUNOTHERAPY Filling date: 7 Sep 2025 Issue date: 3 Dec 2020 | 28 Mar 2018 | 3 Dec 2020 |
| Utility: Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded RNA Filling date: 7 Sep 2025 Issue date: 24 Nov 2020 | 28 Jun 2019 | 24 Nov 2020 |
| Utility: Extended dicer substrate agents and methods for the specific inhibition of gene expression Filling date: 7 Sep 2025 Issue date: 17 Nov 2020 | 20 Oct 2014 | 17 Nov 2020 |
| Utility: Compositions and methods for the treatment of a beta-catenin-associated disease or disorder Filling date: 7 Sep 2025 Issue date: 3 Nov 2020 | 15 Mar 2017 | 3 Nov 2020 |
| Utility: METHODS FOR TREATING HEPATITIS B INFECTION Filling date: 7 Sep 2025 Issue date: 29 Oct 2020 | 7 Jul 2020 | 29 Oct 2020 |
| Utility: METHODS FOR TREATING HEPATITIS B INFECTION Filling date: 7 Sep 2025 Issue date: 29 Oct 2020 | 7 Jul 2020 | 29 Oct 2020 |
