Dicerna Pharmaceuticals, Inc.
COMPOSITIONS AND METHODS FOR THE TREATMENT OF KRAS ASSOCIATED DISEASES OR DISORDERS

Abstract:

Provided herein are methods of treating a KRAS-associated cancer in a subject, comprising administering to the subject a therapeutically-effective amount of a KRAS nucleic acid inhibitor molecule and a therapeutically-effective amount of an MEK inhibitor or an immunotherapeutic agent. Also disclosed herein is a method of potentiating a therapeutic effect of an immunotherapeutic agent against a KRAS-associated cancer, comprising administering to a subject having the KRAS-associated cancer a KRAS nucleic acid inhibitor molecule in an amount sufficient to potentiate the therapeutic effect of the immunotherapeutic agent against the cancer.