| Utility: LYMPHODEPLETION DOSING REGIMENS FOR CELLULAR IMMUNOTHERAPIES Filling date: 8 Sep 2025 Issue date: 1 Sep 2022 | 20 Aug 2020 | 1 Sep 2022 |
| Utility: COMPOSITIONS AND METHODS FOR SEQUENTIAL STACKING OF NUCLEIC ACID SEQUENCES INTO A GENOMIC LOCUS Filling date: 8 Sep 2025 Issue date: 1 Sep 2022 | 24 Jul 2020 | 1 Sep 2022 |
| Utility: ENGINEERED MEGANUCLEASES SPECIFIC FOR RECOGNITION SEQUENCES IN THE HEPATITIS B VIRUS GENOME Filling date: 8 Sep 2025 Issue date: 4 Aug 2022 | 4 Feb 2022 | 4 Aug 2022 |
| Utility: NUCLEIC ACID MOLECULES ENCODING AN ENGINEERED ANTIGEN RECEPTOR AND AN INHIBITORY NUCLEIC ACID MOLECULE AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 21 Jul 2022 | 4 Apr 2022 | 21 Jul 2022 |
| Utility: Genetically-modified immune cells comprising a microRNA-adapted shRNA (shRNAmiR) Filling date: 8 Sep 2025 Issue date: 12 Jul 2022 | 26 Oct 2021 | 12 Jul 2022 |
| Utility: METHODS OF PREPARING POPULATIONS OF GENETICALLY-MODIFIED IMMUNE CELLS Filling date: 8 Sep 2025 Issue date: 30 Jun 2022 | 3 Apr 2020 | 30 Jun 2022 |
| Utility: ENGINEERED NUCLEASES USEFUL FOR TREATMENT OF HEMOPHILIA A Filling date: 8 Sep 2025 Issue date: 23 Jun 2022 | 10 Mar 2022 | 23 Jun 2022 |
| Utility: OPTIMIZATION OF ENGINEERED MEGANUCLEASES FOR RECOGNITION SEQUENCES Filling date: 8 Sep 2025 Issue date: 23 Jun 2022 | 7 May 2020 | 23 Jun 2022 |
| Utility: NUCLEIC ACIDS ENCODING ENGINEERED MEGANUCLEASES WITH RECOGNITION SEQUENCES FOUND IN THE HUMAN T CELL RECEPTOR ALPHA CONSTANT REGION GENE Filling date: 8 Sep 2025 Issue date: 19 May 2022 | 31 Jan 2022 | 19 May 2022 |
| Utility: TREATMENT OF RETINITIS PIGMENTOSA USING ENGINEERED MEGANUCLEASES Filling date: 8 Sep 2025 Issue date: 12 May 2022 | 26 Jan 2022 | 12 May 2022 |
| Utility: GENETICALLY-MODIFIED CELLS COMPRISING A MODIFIED HUMAN T CELL RECEPTOR ALPHA CONSTANT REGION GENE Filling date: 8 Sep 2025 Issue date: 12 May 2022 | 19 Jan 2022 | 12 May 2022 |
| Utility: GENETICALLY-MODIFIED CELLS COMPRISING A MODIFIED HUMAN T CELL RECEPTOR ALPHA CONSTANT REGION GENE Filling date: 8 Sep 2025 Issue date: 5 May 2022 | 19 Jan 2022 | 5 May 2022 |
| Utility: GENETICALLY-MODIFIED CELLS COMPRISING A MODIFIED TRANSFERRIN GENE Filling date: 8 Sep 2025 Issue date: 21 Apr 2022 | 10 Jan 2020 | 21 Apr 2022 |
| Utility: Co-stimulatory domains for use in genetically-modified cells Filling date: 8 Sep 2025 Issue date: 29 Mar 2022 | 4 Oct 2017 | 29 Mar 2022 |
| Utility: GENETIC MODIFICATION OF THE HYDROXYACID OXIDASE 1 GENE FOR TREATMENT OF PRIMARY HYPEROXALURIA Filling date: 8 Sep 2025 Issue date: 24 Mar 2022 | 20 Dec 2019 | 24 Mar 2022 |
| Utility: Engineered nucleases useful for treatment of hemophilia A Filling date: 8 Sep 2025 Issue date: 22 Mar 2022 | 3 May 2017 | 22 Mar 2022 |
| Utility: Engineered meganucleases specific for recognition sequences in the Hepatitis B virus genome Filling date: 8 Sep 2025 Issue date: 15 Mar 2022 | 28 Oct 2020 | 15 Mar 2022 |
| Utility: Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene Filling date: 8 Sep 2025 Issue date: 8 Mar 2022 | 1 Mar 2021 | 8 Mar 2022 |
| Utility: Nucleic acids encoding engineered meganucleases with recognition sequences found in the human T cell receptor alpha constant region gene Filling date: 8 Sep 2025 Issue date: 8 Mar 2022 | 9 Sep 2020 | 8 Mar 2022 |
| Utility: OPTIMIZED ENGINEERED MEGANUCLEASES HAVING SPECIFICITY FOR A RECOGNITION SEQUENCE IN THE HEPATITIS B VIRUS GENOME Filling date: 8 Sep 2025 Issue date: 24 Feb 2022 | 20 Sep 2021 | 24 Feb 2022 |
| Utility: GENETICALLY-MODIFIED IMMUNE CELLS COMPRISING A MICRORNA-ADAPTED SHRNA (SHRNAMIR) Filling date: 8 Sep 2025 Issue date: 10 Feb 2022 | 26 Oct 2021 | 10 Feb 2022 |
| Utility: Genetically-modified immune cells comprising a microRNA-adapted shRNA (shRNAmiR) Filling date: 8 Sep 2025 Issue date: 30 Nov 2021 | 8 Apr 2021 | 30 Nov 2021 |
| Utility: Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome Filling date: 8 Sep 2025 Issue date: 12 Oct 2021 | 11 Apr 2019 | 12 Oct 2021 |
| Utility: GENETICALLY-MODIFIED T CELLS COMPRISING A MODIFIED INTRON IN THE T CELL RECEPTOR ALPHA GENE Filling date: 8 Sep 2025 Issue date: 9 Sep 2021 | 25 May 2021 | 9 Sep 2021 |
| Utility: GENETICALLY-MODIFIED IMMUNE CELLS COMPRISING A MICRORNA-ADAPTED SHRNA (SHRNAMIR) Filling date: 8 Sep 2025 Issue date: 19 Aug 2021 | 8 Apr 2021 | 19 Aug 2021 |
| Utility: PRECISE DELETION OF CHROMOSOMAL SEQUENCES IN VIVO AND TREATMENT OF NUCLEOTIDE REPEAT EXPANSION DISORDERS USING ENGINEERED NUCLEASES Filling date: 8 Sep 2025 Issue date: 29 Jul 2021 | 15 Jan 2021 | 29 Jul 2021 |
| Utility: GENETICALLY-MODIFIED CELLS COMPRISING A MODIFIED HUMAN T CELL RECEPTOR ALPHA CONSTANT REGION GENE Filling date: 8 Sep 2025 Issue date: 8 Jul 2021 | 1 Mar 2021 | 8 Jul 2021 |
| Utility: Genetically-modified T cells comprising a modified intron in the T cell receptor alpha gene Filling date: 8 Sep 2025 Issue date: 6 Jul 2021 | 27 Jun 2018 | 6 Jul 2021 |
| Utility: ENGINEERED MEGANUCLEASES SPECIFIC FOR RECOGNITION SEQUENCES IN THE HEPATITIS B VIRUS GENOME Filling date: 8 Sep 2025 Issue date: 17 Jun 2021 | 28 Oct 2020 | 17 Jun 2021 |
| Utility: DYSTROPHIN GENE EXON DELETION USING ENGINEERED NUCLEASES Filling date: 8 Sep 2025 Issue date: 20 May 2021 | 25 Sep 2020 | 20 May 2021 |
| Utility: Genetically-modified immune cells comprising a microRNA-adapted shRNA (shRNAmiR) Filling date: 8 Sep 2025 Issue date: 18 May 2021 | 22 Jun 2020 | 18 May 2021 |
| Utility: RECOGNITION SEQUENCES FOR I-CREI-DERIVED MEGANUCLEASES AND USES THEREOF Filling date: 8 Sep 2025 Issue date: 6 May 2021 | 7 Oct 2020 | 6 May 2021 |
| Utility: OPTIMIZED ENGINEERED NUCLEASES HAVING SPECIFICITY FOR THE HUMAN T CELL RECEPTOR ALPHA CONSTANT REGION GENE Filling date: 8 Sep 2025 Issue date: 22 Apr 2021 | 11 Apr 2019 | 22 Apr 2021 |
| Utility: RATIONALLY-DESIGNED SINGLE-CHAIN MEGANUCLEASES WITH NON-PALINDROMIC RECOGNITION SEQUENCES Filling date: 8 Sep 2025 Issue date: 25 Feb 2021 | 23 Oct 2020 | 25 Feb 2021 |
| Utility: ENGINEERED MEGANUCLEASES WITH RECOGNITION SEQUENCES FOUND IN THE HUMAN T CELL RECEPTOR ALPHA CONSTANT REGION GENE Filling date: 8 Sep 2025 Issue date: 25 Feb 2021 | 9 Sep 2020 | 25 Feb 2021 |
| Utility: ENGINEERED MEGANUCLEASES WITH RECOGNITION SEQUENCES FOUND IN THE HUMAN BETA-2 MICROGLOBULIN GENE Filling date: 8 Sep 2025 Issue date: 4 Feb 2021 | 19 Oct 2020 | 4 Feb 2021 |
| Utility: TREATMENT OF RETINITIS PIGMENTOSA USING ENGINEERED MEGANUCLEASES Filling date: 8 Sep 2025 Issue date: 7 Jan 2021 | 17 Jul 2020 | 7 Jan 2021 |
| Utility: CO-STIMULATORY DOMAINS FOR USE IN GENETICALLY-MODIFIED CELLS Filling date: 8 Sep 2025 Issue date: 24 Dec 2020 | 9 Sep 2020 | 24 Dec 2020 |
| Utility: Engineered meganucleases specific for recognition sequences in the hepatitis B virus genome Filling date: 8 Sep 2025 Issue date: 1 Dec 2020 | 17 Apr 2020 | 1 Dec 2020 |
| Utility: GENETICALLY-MODIFIED IMMUNE CELLS COMPRISING A MICRORNA-ADAPTED SHRNA (SHRNAMIR) Filling date: 8 Sep 2025 Issue date: 26 Nov 2020 | 22 Jun 2020 | 26 Nov 2020 |
| Utility: NUCLEIC ACID MOLECULES ENCODING AN ENGINEERED ANTIGEN RECEPTOR AND AN INHIBITORY NUCLEIC ACID MOLECULE AND METHODS OF USE THEREOF Filling date: 8 Sep 2025 Issue date: 29 Oct 2020 | 13 Jul 2020 | 29 Oct 2020 |
| Utility: Co-stimulatory domains for use in genetically-modified cells Filling date: 8 Sep 2025 Issue date: 13 Oct 2020 | 11 Oct 2019 | 13 Oct 2020 |
| Utility: Engineered meganucleases with recognition sequences found in the human T cell receptor alpha constant region gene Filling date: 8 Sep 2025 Issue date: 13 Oct 2020 | 5 Oct 2016 | 13 Oct 2020 |
| Utility: SELF-LIMITING VIRAL VECTORS ENCODING NUCLEASES Filling date: 8 Sep 2025 Issue date: 1 Oct 2020 | 14 Apr 2020 | 1 Oct 2020 |
| Utility: ENGINEERED NUCLEASES THAT TARGET HUMAN AND CANINE FACTOR VIII GENES AS A TREATMENT FOR HEMOPHILIA A Filling date: 8 Sep 2025 Issue date: 24 Sep 2020 | 1 Nov 2018 | 24 Sep 2020 |
| Utility: Treatment of retinitis pigmentosa using engineered meganucleases Filling date: 8 Sep 2025 Issue date: 1 Sep 2020 | 14 Feb 2020 | 1 Sep 2020 |
| Utility: Nucleic acid molecules encoding an engineered antigen receptor and an inhibitory nucleic acid molecule and methods of use thereof Filling date: 8 Sep 2025 Issue date: 18 Aug 2020 | 8 Nov 2019 | 18 Aug 2020 |
| Utility: ENGINEERED MEGANUCLEASES SPECIFIC FOR RECOGNITION SEQUENCES IN THE HEPATITIS B VIRUS GENOME Filling date: 8 Sep 2025 Issue date: 30 Jul 2020 | 17 Apr 2020 | 30 Jul 2020 |
| Utility: MODIFIED EPIDERMAL GROWTH FACTOR RECEPTOR PEPTIDES FOR USE IN GENETICALLY-MODIFIED CELLS Filling date: 8 Sep 2025 Issue date: 30 Jul 2020 | 3 Oct 2018 | 30 Jul 2020 |
| Utility: METHODS FOR REDUCING DNA-INDUCED CYTOTOXICITY AND ENHANCING GENE EDITING IN PRIMARY CELLS Filling date: 8 Sep 2025 Issue date: 18 Jun 2020 | 30 Apr 2018 | 18 Jun 2020 |
