Global Blood Therapeutics, Inc.
TRICYCLIC COMPOUNDS AS HISTONE METHYLTRANSFERASE INHIBITORS
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Abstract:
The present disclosure provides tricyclic compounds of formula (I) that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds. ##STR00001##
Status:
Application
Type:
Utility
Filling date:
13 Aug 2018
Issue date:
19 Nov 2020