| Utility: PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS Filling date: 6 Sep 2025 Issue date: 25 Aug 2022 | 7 Feb 2022 | 25 Aug 2022 |
| Utility: PROCESS FOR PREPARATION OF 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALD- EHYDE Filling date: 6 Sep 2025 Issue date: 12 May 2022 | 5 Nov 2021 | 12 May 2022 |
| Utility: PROCESS FOR SYNTHESIZING 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)-PYRIDIN-3-YL)METHOXY)BENZAL- DEHYDE Filling date: 6 Sep 2025 Issue date: 5 May 2022 | 10 Jan 2022 | 5 May 2022 |
| Utility: COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN Filling date: 6 Sep 2025 Issue date: 21 Apr 2022 | 3 Jan 2022 | 21 Apr 2022 |
| Utility: DOSING REGIMENS FOR 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALD- EHYDE Filling date: 6 Sep 2025 Issue date: 14 Apr 2022 | 22 Dec 2021 | 14 Apr 2022 |
| Utility: Ferroportin inhibitors and methods of use Filling date: 6 Sep 2025 Issue date: 29 Mar 2022 | 12 Dec 2019 | 29 Mar 2022 |
| Utility: Histone methyltransferase inhibitors Filling date: 6 Sep 2025 Issue date: 22 Feb 2022 | 15 Feb 2017 | 22 Feb 2022 |
| Utility: Compounds and uses thereof for the modulation of hemoglobin Filling date: 6 Sep 2025 Issue date: 1 Feb 2022 | 18 Mar 2019 | 1 Feb 2022 |
| Utility: AZAINDOLE COMPOUNDS AS HISTONE METHYLTRANSFERASE INHIBITORS Filling date: 6 Sep 2025 Issue date: 2 Dec 2021 | 6 Aug 2021 | 2 Dec 2021 |
| Utility: SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION Filling date: 6 Sep 2025 Issue date: 23 Sep 2021 | 28 May 2021 | 23 Sep 2021 |
| Utility: PROCESS FOR SYNTHESIZING 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)-PYRIDIN-3-YL)METHOXY)BENZAL- DEHYDE Filling date: 6 Sep 2025 Issue date: 16 Sep 2021 | 3 Jun 2021 | 16 Sep 2021 |
| Utility: TABLETS COMPRISING 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALD- EHYDE Filling date: 6 Sep 2025 Issue date: 16 Sep 2021 | 20 Jan 2021 | 16 Sep 2021 |
| Utility: Azaindole compounds as histone methyltransferase inhibitors Filling date: 6 Sep 2025 Issue date: 7 Sep 2021 | 7 Jun 2018 | 7 Sep 2021 |
| Utility: DOSING REGIMENS FOR 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALD- EHYDE Filling date: 6 Sep 2025 Issue date: 2 Sep 2021 | 20 May 2021 | 2 Sep 2021 |
| Utility: COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN Filling date: 6 Sep 2025 Issue date: 26 Aug 2021 | 21 Sep 2020 | 26 Aug 2021 |
| Utility: Compounds and uses thereof for the modulation of hemoglobin Filling date: 6 Sep 2025 Issue date: 6 Jul 2021 | 9 Nov 2018 | 6 Jul 2021 |
| Utility: CRYSTALLINE POLYMORPHS OF THE FREE BASE OF 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALD- EHYDE Filling date: 6 Sep 2025 Issue date: 3 Jun 2021 | 8 Jul 2020 | 3 Jun 2021 |
| Utility: Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzald- ehyde Filling date: 6 Sep 2025 Issue date: 1 Jun 2021 | 2 Dec 2016 | 1 Jun 2021 |
| Utility: Modulators of hemoglobin Filling date: 6 Sep 2025 Issue date: 25 May 2021 | 30 Sep 2019 | 25 May 2021 |
| Utility: HISTONE METHYLTRANSFERASE INHIBITORS Filling date: 6 Sep 2025 Issue date: 15 Apr 2021 | 4 Nov 2020 | 15 Apr 2021 |
| Utility: MODULATORS OF HEMOGLOBIN Filling date: 6 Sep 2025 Issue date: 18 Feb 2021 | 4 May 2020 | 18 Feb 2021 |
| Utility: Compounds and uses thereof for the modulation of hemoglobin Filling date: 6 Sep 2025 Issue date: 8 Dec 2020 | 12 Apr 2019 | 8 Dec 2020 |
| Utility: TRICYCLIC COMPOUNDS AS HISTONE METHYLTRANSFERASE INHIBITORS Filling date: 6 Sep 2025 Issue date: 19 Nov 2020 | 13 Aug 2018 | 19 Nov 2020 |
| Utility: Compounds and uses thereof for the modulation of hemoglobin Filling date: 6 Sep 2025 Issue date: 10 Nov 2020 | 30 Mar 2018 | 10 Nov 2020 |
| Utility: Histone methyltransferase inhibitors Filling date: 6 Sep 2025 Issue date: 10 Nov 2020 | 21 Dec 2017 | 10 Nov 2020 |
| Utility: Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation Filling date: 6 Sep 2025 Issue date: 3 Nov 2020 | 23 Jul 2019 | 3 Nov 2020 |
| Utility: Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation Filling date: 6 Sep 2025 Issue date: 20 Oct 2020 | 25 Jun 2018 | 20 Oct 2020 |
| Utility: Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzald- ehyde Filling date: 6 Sep 2025 Issue date: 28 Jul 2020 | 18 Oct 2018 | 28 Jul 2020 |
| Utility: Methods of treatment Filling date: 6 Sep 2025 Issue date: 30 Jun 2020 | 16 May 2018 | 30 Jun 2020 |
| Utility: FERROPORTIN INHIBITORS AND METHODS OF USE Filling date: 6 Sep 2025 Issue date: 18 Jun 2020 | 12 Dec 2019 | 18 Jun 2020 |
| Utility: SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION Filling date: 6 Sep 2025 Issue date: 18 Jun 2020 | 23 Jul 2019 | 18 Jun 2020 |
| Utility: Modulators of hemoglobin Filling date: 6 Sep 2025 Issue date: 16 Jun 2020 | 18 Nov 2019 | 16 Jun 2020 |
| Utility: MODULATORS OF HEMOGLOBIN Filling date: 6 Sep 2025 Issue date: 21 May 2020 | 18 Nov 2019 | 21 May 2020 |
| Utility: MODULATORS OF HEMOGLOBIN Filling date: 6 Sep 2025 Issue date: 7 May 2020 | 30 Sep 2019 | 7 May 2020 |
| Utility: COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN Filling date: 6 Sep 2025 Issue date: 12 Mar 2020 | 12 Apr 2019 | 12 Mar 2020 |
| Utility: Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzal- dehyde Filling date: 6 Sep 2025 Issue date: 3 Mar 2020 | 10 Aug 2018 | 3 Mar 2020 |
| Utility: COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN Filling date: 6 Sep 2025 Issue date: 13 Feb 2020 | 18 Mar 2019 | 13 Feb 2020 |
| Utility: Tablets comprising 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzald- ehyde Filling date: 6 Sep 2025 Issue date: 3 Dec 2019 | 12 Oct 2017 | 3 Dec 2019 |
| Utility: Compounds and uses thereof for the modulation of hemoglobin Filling date: 6 Sep 2025 Issue date: 22 Oct 2019 | 19 Jun 2019 | 22 Oct 2019 |
| Utility: Compounds and uses thereof for the modulation of hemoglobin Filling date: 6 Sep 2025 Issue date: 8 Oct 2019 | 2 Jul 2015 | 8 Oct 2019 |
| Utility: COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN Filling date: 6 Sep 2025 Issue date: 3 Oct 2019 | 19 Jun 2019 | 3 Oct 2019 |
| Utility: CRYSTALLINE POLYMORPHS OF THE FREE BASE OF 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALD- EHYDE Filling date: 6 Sep 2025 Issue date: 22 Aug 2019 | 18 Oct 2018 | 22 Aug 2019 |
| Utility: Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation Filling date: 6 Sep 2025 Issue date: 13 Aug 2019 | 8 Jan 2018 | 13 Aug 2019 |
