Global Blood Therapeutics, Inc.
Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation

Abstract:

Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.