Global Blood Therapeutics, Inc.
PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS
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Abstract:
The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.
Status:
Application
Type:
Utility
Filling date:
7 Feb 2022
Issue date:
25 Aug 2022