Global Blood Therapeutics, Inc.
PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS

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Abstract:

The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.

Status:
Application
Type:

Utility

Filling date:

7 Feb 2022

Issue date:

25 Aug 2022