Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 535,534 $0.75 $401,651 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 248,819 $0.75 $186,614 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 38,327 $0.75 $28,745 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 153,078 $3 $459,234 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 29,700 $3 $89,100 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 26,622 $3 $79,866 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 26,700 $2.92 $77,964 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 4,700 $2.92 $13,724 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 7,800 $2.92 $22,776 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 132,100 $2.4 $317,040 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 52,800 $2.4 $126,720 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 9,800 $2.4 $23,520 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 3,551 $1.97 $6,995 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 8,878 $1.97 $17,490 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 660 $1.97 $1,300 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 2,091 $1.86 $3,889 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 11,245 $1.86 $20,916 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 28,110 $1.86 $52,285 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 703 $1.82 $1,279 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 3,784 $1.82 $6,887 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 9,459 $1.82 $17,215 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 119 $1.81 $215 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 641 $1.81 $1,160 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 1,603 $1.81 $2,901 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 703 $1.82 $1,279 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 3,784 $1.82 $6,887 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 9,459 $1.82 $17,215 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 2,584 $1.79 $4,625 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 13,899 $1.79 $24,879 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 34,745 $1.79 $62,194 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 487 $2 $974 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 2,620 $2 $5,240 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 6,558 $2 $13,116 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 4,687 $2.18 $10,218 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 25,220 $2.18 $54,980 Sale
ORBIMED ADVISORS LLC 10 percent owner 10 percent owner
Common Stock 63,058 $2.18 $137,466 Purchase
SCHAMBYE HANS T. director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 5,000 $2.15 $10,750 Purchase
LINDMARK BERTIL officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 14,604 $2.16 $31,545 Purchase
FREVE JONATHAN officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 4,000 $2.49 $9,960 Purchase
WINSLOW GARRETT officer: General Counsel officer: General Counsel
Common Stock 2,000 $2.48 $4,960 Purchase
SCHAMBYE HANS T. director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 4,500 $3.5 $15,750 Purchase
FREVE JONATHAN officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 3,000 $3.4 $10,200 Purchase
FREVE JONATHAN
Common Stock 3,000 $3.92 $11,760 Purchase
LINDMARK BERTIL
Common Stock 2,000 N/A N/A Purchase
SCHAMBYE HANS T.
Common Stock 3,000 N/A N/A Purchase
WINSLOW GARRETT
Common Stock 2,000 N/A N/A Purchase
FREVE JONATHAN
Common Stock 2,000 $4.74 $9,480 Purchase
CHRISTGAU STEPHAN
Common Stock 66,666 $15 $999,990 Purchase
KHUONG CHAU QUANG
Common Shares 733,333 $15 $10,999,995 Purchase
ORBIMED ADVISORS LLC
Common Shares 733,333 N/A N/A