Option
LEWIS WILLIAM director, officer: Chair and CEO director, officer: Chair and CEO
Common Stock 315 $14.24 $4,486 Sale
LEWIS WILLIAM director, officer: Chair and CEO director, officer: Chair and CEO
Common Stock 55,000 $25.04 $1,377,200 Option
LEWIS WILLIAM director, officer: Chair and CEO director, officer: Chair and CEO
Stock Option (right to buy) 57,000 $14.24 $811,680 Sale
SMITH MICHAEL ALEXANDER officer: General Counsel, Senior VP officer: General Counsel, Senio..
Common Stock 740 $20.18 $14,933 Sale
FLAMMER MARTINA M.D. officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 8,868 $19.27 $170,886 Sale
ADSETT ROGER officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 8,981 $19.32 $173,513 Sale
WISE JOHN DRAYTON officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 3,366 $18.95 $63,786 Sale
WISE JOHN DRAYTON officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 1,913 $18.17 $34,759 Sale
SMITH MICHAEL ALEXANDER officer: General Counsel, Senior VP officer: General Counsel, Senio..
Common Stock 1,263 $18.18 $22,961 Sale
SCHAEFFER ORLOV S NICOLE officer: Chief People Strategy Of.. officer: Chief People Strategy ..
Common Stock 1,972 $18.16 $35,812 Sale
LEWIS WILLIAM director, officer: Chair and CEO director, officer: Chair and CEO
Common Stock 7,099 $18.12 $128,634 Sale
ADSETT ROGER officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 2,448 $18.12 $44,358 Sale
WISE JOHN DRAYTON officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 381 $18.44 $7,026 Sale
SMITH MICHAEL ALEXANDER officer: General Counsel, Senior VP officer: General Counsel, Senio..
Common Stock 475 $18.43 $8,754 Sale
SCHAEFFER ORLOV S NICOLE officer: Chief People Strategy Of.. officer: Chief People Strategy ..
Common Stock 1,217 $18.45 $22,454 Sale
LEWIS WILLIAM director, officer: Chair and CEO director, officer: Chair and CEO
Common Stock 3,714 $18.41 $68,375 Sale
FLAMMER MARTINA M.D. officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 1,718 $18.43 $31,663 Sale
BONSTEIN SARA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 1,610 $18.47 $29,737 Sale
ADSETT ROGER officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 1,521 $18.39 $27,971 Sale
WISE JOHN DRAYTON officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 593 $19.29 $11,439 Sale
SMITH MICHAEL ALEXANDER officer: General Counsel, Senior VP officer: General Counsel, Senio..
Common Stock 1,897 $19.24 $36,498 Sale
SCHAEFFER ORLOV S NICOLE officer: Chief People Strategy Of.. officer: Chief People Strategy ..
Common Stock 1,830 $19.22 $35,173 Sale
LEWIS WILLIAM director, officer: Chair and CEO director, officer: Chair and CEO
Common Stock 6,048 $19.23 $116,303 Sale
FLAMMER MARTINA M.D. officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 2,576 $19.28 $49,665 Sale
BONSTEIN SARA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 2,210 $19.3 $42,653 Sale
ADSETT ROGER officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 2,847 $19.27 $54,862 Purchase
SHAROKY MELVIN MD director director
Common Stock 10,000 $19.29 $192,900 Purchase
SHAROKY MELVIN MD director director
Common Stock 10,000 $19.29 $192,900 Option
LEWIS WILLIAM director, officer: Chair and CEO director, officer: Chair and CEO
Common Stock 67,257 $12.44 $836,677 Option
LEWIS WILLIAM director, officer: Chair and CEO director, officer: Chair and CEO
Common Stock 83,333 $12.44 $1,036,663 Option
LEWIS WILLIAM director, officer: Chair and CEO director, officer: Chair and CEO
Common Stock 83,334 $12.44 $1,036,675 Option
LEWIS WILLIAM director, officer: Chair and CEO director, officer: Chair and CEO
Stock Option (right to buy) 83,334 $12.44 $1,036,675 Option
LEWIS WILLIAM director, officer: Chair and CEO director, officer: Chair and CEO
Stock Option 83,333 $12.44 $1,036,663 Sale
WISE JOHN DRAYTON officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 779 $17.96 $13,991 Sale
SCHAEFFER ORLOV S NICOLE officer: Chief People Strategy Of.. officer: Chief People Strategy ..
Common Stock 2,435 $17.95 $43,708 Sale
SMITH MICHAEL ALEXANDER officer: General Counsel, Senior VP officer: General Counsel, Senio..
Common Stock 1,836 $17.93 $32,919 Sale
LEWIS WILLIAM director, officer: Chair and CEO director, officer: Chair and CEO
Common Stock 6,994 $18 $125,892 Sale
FLAMMER MARTINA M.D. officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 3,439 $18.06 $62,108 Sale
ADSETT ROGER officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 3,194 $17.99 $57,460 Sale
BONSTEIN SARA officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 2,857 $18.12 $51,769 Sale
WISE JOHN DRAYTON officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 1,160 $19.74 $22,898 Sale
SMITH MICHAEL ALEXANDER officer: General Counsel, Senior VP officer: General Counsel, Senio..
Common Stock 720 $19.72 $14,198 Sale
SCHAEFFER ORLOV S NICOLE officer: Chief People Strategy Of.. officer: Chief People Strategy ..
Common Stock 1,448 $19.73 $28,569 Sale
LEWIS WILLIAM director, officer: Chair and CEO director, officer: Chair and CEO
Common Stock 7,008 $19.8 $138,758 Sale
FLAMMER MARTINA M.D. officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 1,374 $19.73 $27,109 Sale
ADSETT ROGER officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 3,044 $19.75 $60,119 Sale
WISE JOHN DRAYTON officer: Chief Commercial Officer officer: Chief Commercial Officer
Common Stock 7,154 $18.84 $134,781 Sale
ADSETT ROGER officer: Chief Operating Officer officer: Chief Operating Officer
Common Stock 11,855 $18.8 $222,874 Purchase
SHAROKY MELVIN MD director director
Common Stock 10,000 $17.7 $177,000 Purchase
LEE LEO director director
Common Stock 45,000 $17.69 $796,050 
