Sale
WHITE WILLIAM RICHARD director director
Common Stock 337 $50.29 $16,947 Sale
WHITE WILLIAM RICHARD director director
Common Stock 50 $51.54 $2,577 Sale
WHITE WILLIAM RICHARD director director
Common Stock 10 $52.28 $523 Sale
SAVAGE WILLIAM JACOB officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 1,500 $50.59 $75,885 Option
WHITE WILLIAM RICHARD director director
Stock Option (Right to Buy) 201 $9.86 $1,982 Option
WHITE WILLIAM RICHARD director director
Common Stock 201 $9.86 $1,982 Sale
WHITE WILLIAM RICHARD director director
Common Stock 144 $43.24 $6,226 Sale
WHITE WILLIAM RICHARD director director
Common Stock 57 $43.95 $2,505 Option
QUISEL JOHN D director, officer: Chief Executive Officer director, officer: Chief Execut..
Stock Option (Right to Buy) 3,000 $1.01 $3,030 Option
QUISEL JOHN D director, officer: Chief Executive Officer director, officer: Chief Execut..
Common Stock 3,000 $1.01 $3,030 Option
WHITE WILLIAM RICHARD director director
Stock Option (Right to Buy) 201 $9.86 $1,982 Option
WHITE WILLIAM RICHARD director director
Common Stock 201 $9.86 $1,982 Sale
WHITE WILLIAM RICHARD director director
Common Stock 18 $45.07 $811 Sale
WHITE WILLIAM RICHARD director director
Common Stock 109 $45.92 $5,005 Sale
WHITE WILLIAM RICHARD director director
Common Stock 74 $46.45 $3,437 Purchase
BITTERMAN KEVIN director director
Common Stock 222,223 $36 $8,000,028 Purchase
ASHIYA MONA director director
Common Stock 43,944 $36 $1,581,984 Purchase
ASHIYA MONA director director
Common Stock 28,404 $36 $1,022,544 Purchase
ASHIYA MONA director director
Common Stock 10,986 $36 $395,496 Purchase
ORBIMED ADVISORS LLC director director
Common Stock 43,944 $36 $1,581,984 Purchase
ORBIMED ADVISORS LLC director director
Common Stock 28,404 $36 $1,022,544 Purchase
ORBIMED ADVISORS LLC director director
Common Stock 10,986 $36 $395,496 Option
WHITE WILLIAM RICHARD director director
Stock Option (Right to Buy) 1,756 $2.65 $4,653 Option
WHITE WILLIAM RICHARD director director
Stock Option (Right to Buy) 201 $9.86 $1,982 Sale
WHITE WILLIAM RICHARD director director
Common Stock 1,755 $36.1 $63,359 Sale
WHITE WILLIAM RICHARD director director
Common Stock 95 $36.72 $3,488 Sale
WHITE WILLIAM RICHARD director director
Common Stock 107 $35.15 $3,761 Option
WHITE WILLIAM RICHARD director director
Common Stock 1,756 $2.65 $4,653 Option
WHITE WILLIAM RICHARD director director
Common Stock 201 $9.86 $1,982 Option
WHITE WILLIAM RICHARD director director
Stock Option (Right to Buy) 201 $9.86 $1,982 Option
WHITE WILLIAM RICHARD director director
Common Stock 201 $9.86 $1,982 Sale
WHITE WILLIAM RICHARD director director
Common Stock 39 $29.12 $1,135 Sale
WHITE WILLIAM RICHARD director director
Common Stock 162 $28.52 $4,619 Option
WHITE WILLIAM RICHARD director director
Stock Option (Right to Buy) 1,756 $2.65 $4,653 Option
WHITE WILLIAM RICHARD director director
Stock Option (Right to Buy) 804 $9.86 $7,927 Option
WHITE WILLIAM RICHARD director director
Common Stock 804 $9.86 $7,927 Option
WHITE WILLIAM RICHARD director director
Common Stock 1,756 $2.65 $4,653 Sale
WHITE WILLIAM RICHARD director director
Common Stock 2,482 $31.79 $78,898 Sale
WHITE WILLIAM RICHARD director director
Common Stock 78 $32.18 $2,510 Option
SAVAGE WILLIAM JACOB officer: Chief Medical Officer officer: Chief Medical Officer
Common Stock 21,870 $2.65 $57,956 Option
SAVAGE WILLIAM JACOB officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (Right to Buy) 13,093 $2.65 $34,696 Option
SAVAGE WILLIAM JACOB officer: Chief Medical Officer officer: Chief Medical Officer
Stock Option (Right to Buy) 8,777 $2.65 $23,259 Sale
BITTERMAN KEVIN director director
Common Stock 26,157 $73.5 $1,922,540 Sale
ATLAS VENTURE FUND X, L.P. 10 percent owner 10 percent owner
Common Stock 47,500 $67.65 $3,213,375 Sale
ATLAS VENTURE FUND X, L.P. 10 percent owner 10 percent owner
Common Stock 82,500 $67.65 $5,581,125 Sale
BITTERMAN KEVIN director director
Common Stock 82,500 $67.65 $5,581,125 Sale
BITTERMAN KEVIN director director
Common Stock 20,000 $67.65 $1,353,000 Sale
ATLAS VENTURE FUND X, L.P. 10 percent owner 10 percent owner
Common Stock 20,000 $67.65 $1,353,000 Purchase
ASHIYA MONA director, 10 percent owner director, 10 percent owner
Common Stock 14,329 $23 $329,567 Purchase
ASHIYA MONA director, 10 percent owner director, 10 percent owner
Common Stock 37,049 $23 $852,127 
