Option
SEBULSKY ALAN director director
Option (right to buy) 9,036 $15.09 $136,353 Purchase
FALBERG KATHRYN E officer: EVP and CFO officer: EVP and CFO
Common Stock 3,000 $37.36 $112,080 Option
DESJARDIN MICHAEL A. officer: SVP, Product Development officer: SVP, Product Development
Common Stock 709 N/A N/A Option
ELLER MARK G. officer: SVP, Research & Clinical Dev. officer: SVP, Research & Clinic..
Common Stock 690 N/A N/A Option
ELLER MARK G. officer: SVP, Research & Clinical Dev. officer: SVP, Research & Clinic..
Restricted Stock Units 690 N/A N/A Option
DESJARDIN MICHAEL A. officer: SVP, Product Development officer: SVP, Product Development
Restricted Stock Units 709 N/A N/A Sale
KKR GROUP HOLDINGS L.P. 10 percent owner, other: See Footn.. 10 percent owner, other: See Fo..
Common Stock 53,964 $36.04 $1,945,024 Sale
KKR FINANCIAL HOLDINGS III, LLC other: See Footnotes (2) -.. other: See Footnotes (2) - (9)
Common Stock 53,964 $36.04 $1,945,024 Sale
KKR FINANCIAL HOLDINGS III, LLC other: See Footnotes (2) -.. other: See Footnotes (2) - (9)
Common Stock 16,192 $40.47 $655,290 Sale
KKR GROUP HOLDINGS L.P. 10 percent owner, other: See Footn.. 10 percent owner, other: See Fo..
Common Stock 16,192 $40.47 $655,290 Sale
WISSEL JANNE LT officer: SVP, Chief Regulatory Officer officer: SVP, Chief Regulatory ..
Common Stock 59,500 $18.38 $1,093,610 Sale
WISSEL JANNE LT officer: SVP, Chief Regulatory Officer officer: SVP, Chief Regulatory ..
Common Stock 500 $18.75 $9,375 Option
GAMBLE CAROL A officer: SVP and General Counsel officer: SVP and General Counsel
Common Stock 25,000 $4.61 $115,125 Sale
GAMBLE CAROL A officer: SVP and General Counsel officer: SVP and General Counsel
Common Stock 25,000 $17.77 $444,250 Option
GAMBLE CAROL A officer: SVP and General Counsel officer: SVP and General Counsel
Option (right to buy) 25,000 $4.61 $115,125 Sale
GAMBLE CAROL A officer: SVP and General Counsel officer: SVP and General Counsel
Common Stock 56,129 $8.19 $459,697 Option
GAMBLE CAROL A officer: SVP and General Counsel officer: SVP and General Counsel
Option (right to buy) 40,000 $1.25 $50,000 Option
GAMBLE CAROL A officer: SVP and General Counsel officer: SVP and General Counsel
Common Stock 40,000 $1.25 $50,000 Option
WISSEL JANNE LT officer: SVP, Chief Regulatory Officer officer: SVP, Chief Regulatory ..
Option (right to buy) 46,663 $1.25 $58,329 Option
WISSEL JANNE LT officer: SVP, Chief Regulatory Officer officer: SVP, Chief Regulatory ..
Common Stock 46,663 $1.25 $58,329 Sale
WISSEL JANNE LT officer: SVP, Chief Regulatory Officer officer: SVP, Chief Regulatory ..
Common Stock 46,663 $1.25 $58,329 Purchase
MYERS ROBERT M director, officer: President director, officer: President
Common Stock 6,000 $9.76 $58,560 Purchase
FALBERG KATHRYN E officer: EVP and CFO officer: EVP and CFO
Common Stock 24,311 $8.93 $217,097 Purchase
COZADD BRUCE C director, officer: Chairman & CEO director, officer: Chairman & CEO
Common Stock 10,000 $8.6 $86,000 Purchase
FALBERG KATHRYN E officer: EVP and CFO officer: EVP and CFO
Common Stock 25,689 $8.53 $219,127 Purchase
ENRIGHT PATRICK G director director
Common Stock 838,323 $8.35 $6,999,997 Sale
GAMBLE CAROL A officer: SVP and General Counsel officer: SVP and General Counsel
Common Stock 14,467 $11.43 $165,300 Sale
MYERS ROBERT M director, officer: President director, officer: President
Common Stock 4,631 $11.46 $53,048 Sale
MYERS ROBERT M director, officer: President director, officer: President
Common Stock 10,369 $11.51 $119,378 Sale
MYERS ROBERT M director, officer: President director, officer: President
Common Stock 5,500 $7.49 $41,173 Purchase
SEBULSKY ALAN director director
Common Stock 19,576 $6.85 $133,998 Sale
GAMBLE CAROL A officer: SVP and General Counsel officer: SVP and General Counsel
Common Stock 3,500 $9.38 $32,820 Purchase
ENRIGHT PATRICK G director director
Common Stock 72,900 $7.22 $526,338 Purchase
ENRIGHT PATRICK G director director
Common Stock 77,100 $7.21 $556,045 Sale
COLLIGAN JOAN officer: Principal Accounting Officer officer: Principal Accounting O..
Common Stock 93 $6.97 $648 Purchase
MICHELSON MICHAEL W director director
Common Stock Warrants (right to buy) 1,328,527 $7.37 $9,791,244 Purchase
CRESSEY BRYAN C director, other: See Footnotes (1) (2) director, other: See Footnotes ..
Common Stock Warrant (right to buy) 137,962 $3.69 $508,390 Purchase
CRESSEY BRYAN C director, other: See Footnotes (1) (2) director, other: See Footnotes ..
Common Stock 306,583 N/A N/A Purchase
TANANBAUM JAMES B director director
Common Stock Warrant (right to buy) 85,650 $3.69 $315,620 Purchase
TANANBAUM JAMES B director director
Common Stock 190,334 N/A N/A Purchase
MICHELSON MICHAEL W director director
Common Stock 1,328,527 $7.37 $9,791,244 Purchase
RAETHER PAUL E other: see footnotes (2) - (7) other: see footnotes (2) - (7)
Common Stock Warrants (right to buy) 1,328,527 $7.37 $9,791,244 Purchase
RAETHER PAUL E other: see footnotes (2) - (7) other: see footnotes (2) - (7)
Common Stock 1,328,527 $7.37 $9,791,244 Purchase
COLELLA SAMUEL D director director
Common Stock Warrant (right to buy) 133,209 $2.46 $327,295 Purchase
COLELLA SAMUEL D director director
Common Stock 296,022 N/A N/A Purchase
O'KEEFE KENNETH W director director
Common Stock Warrant (right to buy) 91,975 $7.37 $677,856 Purchase
O'KEEFE KENNETH W director director
Common Stock 204,389 N/A N/A Purchase
KKR JP LLC 10 percent owner, other: See Footnotes (1) - (6) 10 percent owner, other: See Fo..
Common Stock Warrants (right to buy) 1,328,527 $7.37 $9,791,244 Purchase
KKR JP LLC 10 percent owner, other: See Footnotes (1) - (6) 10 percent owner, other: See Fo..
Common Stock 1,328,527 $7.37 $9,791,244 Purchase
BRIDGER MANAGEMENT LLC 10 percent owner 10 percent owner
Common Stock, par value $.0001 per share 9,940 $8.47 $84,192 
