Option
PATEL SANJ K director, officer: Chairman & CEO director, officer: Chairman & CEO
Share Option 150,700 N/A N/A Sale
PATEL SANJ K director, officer: Chairman & CEO director, officer: Chairman & CEO
Class A Common Shares 250,030 $21.02 $5,255,631 Sale
PATEL SANJ K director, officer: Chairman & CEO director, officer: Chairman & CEO
Class A Common Shares 250,030 N/A N/A Option
PATEL SANJ K director, officer: Chairman & CEO director, officer: Chairman & CEO
Class A Common Shares 872 $1.59 $1,386 Option
PATEL SANJ K director, officer: Chairman & CEO director, officer: Chairman & CEO
Share Option 872 $1.59 $1,386 Sale
PATEL SANJ K director, officer: Chairman & CEO director, officer: Chairman & CEO
Class A Common Shares 1,542 $0.8 $1,226 Sale
BEETHAM THOMAS W. officer: EVP & Chief Legal Officer officer: EVP & Chief Legal Offi..
Class A Common Shares 29,589 $25.58 $756,887 Sale
BEETHAM THOMAS W. officer: EVP & Chief Legal Officer officer: EVP & Chief Legal Offi..
Class A Common Shares 29,589 N/A N/A Option
BEETHAM THOMAS W. officer: EVP & Chief Legal Officer officer: EVP & Chief Legal Offi..
Class A Common Shares 13,752 $1.59 $21,866 Option
BEETHAM THOMAS W. officer: EVP & Chief Legal Officer officer: EVP & Chief Legal Offi..
Share Option 13,752 N/A N/A Sale
BEETHAM THOMAS W. officer: EVP & Chief Legal Officer officer: EVP & Chief Legal Offi..
Class A Common Shares 13,752 N/A N/A Sale
BEETHAM THOMAS W. officer: EVP & Chief Legal Officer officer: EVP & Chief Legal Offi..
Class A Common Shares 2,518 $20 $50,360 Sale
BEETHAM THOMAS W. officer: EVP & Chief Legal Officer officer: EVP & Chief Legal Offi..
Class A Common Shares 2,518 N/A N/A Sale
BEETHAM THOMAS W. officer: EVP & Chief Legal Officer officer: EVP & Chief Legal Offi..
Class A Common Shares 47,423 $19.06 $903,882 Sale
PATEL SANJ K director, officer: Chairman & CEO director, officer: Chairman & CEO
Class A Common Shares 33,115 $20 $662,300 Option
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Share Option 12,000 N/A N/A Option
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Class A Common Shares 12,000 N/A N/A Option
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Share Option 9,803 N/A N/A Option
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Class A Common Shares 9,803 $3.8 $37,251 Sale
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Class A Common Shares 9,803 $19.12 $187,384 Sale
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Class A Common Shares 9,803 $19.12 $187,384 Option
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Share Option 22,477 $3.8 $85,413 Sale
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Class A Common Shares 22,477 $3.8 $85,413 Option
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Class A Common Shares 22,477 $3.8 $85,413 Option
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Class A Common Shares 1,039 N/A N/A Sale
BEETHAM THOMAS W. officer: EVP & Chief Legal Officer officer: EVP & Chief Legal Offi..
Class A Common Shares 59 $18.58 $1,096 Sale
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Class A Common Shares 1,039 N/A N/A Option
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Share Option 1,039 $18.33 $19,045 Option
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Class A Common Shares 10,277 N/A N/A Sale
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Class A Common Shares 10,277 N/A N/A Option
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Share Option 10,277 N/A N/A Option
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Share Option 8,000 N/A N/A Option
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Class A Common Shares 8,000 N/A N/A Option
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Class A Common Shares 10,000 N/A N/A Option
PAOLINI JOHN F. officer: SVP & Chief Medical Officer officer: SVP & Chief Medical Of..
Share Option 10,000 N/A N/A Purchase
BAKER BROS. ADVISORS LP director director
Class A Common Shares 3,000,000 N/A N/A Purchase
BAKER BROS. ADVISORS LP director director
Class A Common Shares 3,000,000 $18 $54,000,000 Purchase
FLYNN JAMES E 10 percent owner, other: *Possible member of.. 10 percent owner, other: *Possi..
Class A Common Stock 843,352 $19.49 $16,436,930 Purchase
FLYNN JAMES E 10 percent owner, other: *Possible member of.. 10 percent owner, other: *Possi..
Class A Common Stock 843,352 N/A N/A Purchase
CORMORANT ASSET MANAGEMENT, LP 10 percent owner 10 percent owner
Common Shares 69,444 N/A N/A Purchase
BEETHAM THOMAS W. officer: EVP & Chief Legal Officer officer: EVP & Chief Legal Offi..
Series C Preferred Shares 6,392 N/A N/A Purchase
BOESS CARSTEN 10 percent owner 10 percent owner
Series C Preferred Shares 6,392 N/A N/A Purchase
MAHONEY STEPHEN F. officer: President & COO officer: President & COO
Series C Preferred Shares 6,392 N/A N/A Purchase
PATEL SANJ K director, officer: Chairman & CEO director, officer: Chairman & CEO
Series C Preferred Shares 63,922 N/A N/A Purchase
BAKER BROS. ADVISORS LP director director
Series C Preferred 4,155,000 N/A N/A Purchase
HEBERLIG CHRIS officer: EVP & CFO officer: EVP & CFO
Series C Preferred Shares 6,392 N/A N/A