Sale
SUTTER MARTIN P director director
Common Stock 1,415,968 $0.19 $264,786 Sale
SUTTER MARTIN P director director
Common Stock 112,880 $0.19 $20,883 Sale
SUTTER MARTIN P director director
Common Stock 112,880 $0.19 $20,883 Sale
SLOAN GAIL A officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 2,230 N/A N/A Sale
BIOMARIN PHARMACEUTICAL INC 10 percent owner 10 percent owner
Common Stock 2,546,958 $0.21 $524,673 Sale
BIOMARIN PHARMACEUTICAL INC 10 percent owner 10 percent owner
Common Stock 2,198,825 $0.21 $461,753 Sale
SLOAN GAIL A officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 4,914 N/A N/A Sale
BIOMARIN PHARMACEUTICAL INC 10 percent owner 10 percent owner
Common Stock 960,950 $0.23 $216,214 Sale
ESSEX WOODLANDS HEALTH VENTURES FUND VII LP 10 percent owner 10 percent owner
Common Stock 3,328,747 $0.05 $173,095 Sale
TOPPER JAMES N director director
Common Stock 2,756,711 $0.06 $154,376 Sale
ESSEX WOODLANDS HEALTH VENTURES FUND VI L P 10 percent owner 10 percent owner
Common Stock 4,236,586 $0.05 $220,302 Sale
FILDES ROBERT PHD director director
Common Stock 16,612 $0.05 $864 Sale
SMITH CRAIG R director director
Common Stock 27,200 $0.06 $1,523 Sale
TOPPER JAMES N director director
Common Stock 1,454,000 $0.06 $91,602 Sale
ESSEX WOODLANDS HEALTH VENTURES FUND VII LP 10 percent owner 10 percent owner
Common Stock 1,717,737 $0.06 $109,935 Sale
ESSEX WOODLANDS HEALTH VENTURES FUND VI L P 10 percent owner 10 percent owner
Common Stock 2,186,211 $0.06 $139,918 Sale
ESSEX WOODLANDS HEALTH VENTURES FUND VII LP 10 percent owner 10 percent owner
Common Stock 1,700,312 $0.07 $125,823 Sale
FRAZIER HEALTHCARE V, LP 10 percent owner 10 percent owner
Common Stock 1,662,000 $0.07 $121,326 Sale
ESSEX WOODLANDS HEALTH VENTURES FUND VI L P 10 percent owner 10 percent owner
Common Stock 2,164,033 $0.07 $160,138 Sale
ELCHICO JOSEFINA T officer: VP Quality Operations officer: VP Quality Operations
Common Stock 25,759 $0.1 $2,576 Sale
TOPPER JAMES N director director
Common Stock 1,662,000 $0.07 $121,326 Sale
GONZALEZ ALEJANDRO 10 percent owner 10 percent owner
Common Stock 8,205,692 $0.2 $1,641,138 Purchase
SUTTER MARTIN P director director
Common Stock 31,091 $1.48 $46,015 Purchase
SUTTER MARTIN P director director
Common Stock 68,909 $1.37 $94,130 Purchase
ESSEX WOODLANDS HEALTH VENTURES FUND VII LP 10 percent owner 10 percent owner
Common Stock 7,807,415 $1.89 $14,756,014 Purchase
ESSEX WOODLANDS HEALTH VENTURES FUND VII LP 10 percent owner 10 percent owner
Warrant 1,951,854 $0.13 $243,982 Purchase
FRAZIER HEALTHCARE V, LP 10 percent owner 10 percent owner
Warrants 259,844 $2.15 $558,665 Purchase
FRAZIER HEALTHCARE V, LP 10 percent owner 10 percent owner
Common Stock 1,039,378 $1.89 $1,964,424 Purchase
GONZALEZ ALEJANDRO 10 percent owner 10 percent owner
Warrants 404,814 $0.13 $50,602 Purchase
GONZALEZ ALEJANDRO 10 percent owner 10 percent owner
Common Stock 1,619,256 $1.89 $3,060,394 Purchase
ESSEX WOODLANDS HEALTH VENTURES FUND VI L P 10 percent owner 10 percent owner
Common Stock 2,081,977 $1.89 $3,934,937 Purchase
ESSEX WOODLANDS HEALTH VENTURES FUND VI L P 10 percent owner 10 percent owner
Warrant 520,494 $0.13 $65,062 Purchase
SUTTER MARTIN P director director
Warrant 1,951,854 $0.13 $243,982 Purchase
SUTTER MARTIN P director director
Common Stock 9,889,392 $0.95 $9,345,475 Purchase
SUTTER MARTIN P director director
Warrant (right to buy) 520,494 N/A N/A Purchase
SUTTER MARTIN P director director
Common Stock 9,889,392 $1.89 $18,690,951 Purchase
GONZALEZ ALEJANDRO 10 percent owner 10 percent owner
Common Stock 551,100 $2.12 $1,168,332 Sale
ELCHICO JOSEFINA T officer: VP Quality Operations officer: VP Quality Operations
Common Stock 400 $3.9 $1,560 Purchase
GONZALEZ ALEJANDRO 10 percent owner 10 percent owner
Common Stock 50,000 $3.93 $196,300 Purchase
GONZALEZ ALEJANDRO 10 percent owner 10 percent owner
Common Stock 57,508 N/A N/A Purchase
GONZALEZ ALEJANDRO 10 percent owner 10 percent owner
Common Stock 75,000 $4.45 $333,750 Purchase
GONZALEZ ALEJANDRO 10 percent owner 10 percent owner
Common Stock 10,000 $4.45 $44,500 Purchase
GONZALEZ ALEJANDRO 10 percent owner 10 percent owner
Common Stock 13,000 $4.27 $55,510 Purchase
GONZALEZ ALEJANDRO 10 percent owner 10 percent owner
Common Stock 400,000 $4.62 $1,848,000 Purchase
ESSEX WOODLANDS HEALTH VENTURES FUND VI L P 10 percent owner 10 percent owner
Common Stock 1,000,000 $6 $6,000,000 Purchase
NAINI NADER J director director
Common Stock 833,333 $6 $4,999,998 Purchase
TOPPER JAMES N director director
Common Stock 833,333 $6 $4,999,998 Purchase
SUTTER MARTIN P director director
Common Stock 1,000,000 $6 $6,000,000 Purchase
GONZALEZ ALEJANDRO 10 percent owner 10 percent owner
Common Stock 833,333 $6 $4,999,998 Purchase
FRAZIER HEALTHCARE V, LP 10 percent owner 10 percent owner
Common Stock 833,333 $6 $4,999,998