| Utility: DE-IMMUNIZED, SHIGA TOXIN A SUBUNIT SCAFFOLDS AND CELL-TARGETING MOLECULES COMPRISING THE SAME Filling date: 18 Sep 2025 Issue date: 8 Sep 2022 | 17 May 2022 | 8 Sep 2022 |
| Utility: DE-IMMUNIZED SHIGA TOXIN A SUBUNIT EFFECTOR POLYPEPTIDES FOR APPLICATIONS IN MAMMALS Filling date: 18 Sep 2025 Issue date: 1 Sep 2022 | 11 Jun 2021 | 1 Sep 2022 |
| Utility: PROTEINS COMPRISING BINDING REGIONS, SHIGA TOXIN A SUBUNIT EFFECTOR REGIONS, AND CARBOXY-TERMINAL, ENDOPLASMIC RETICULUM LOCALIZATION SIGNAL MOTIFS Filling date: 18 Sep 2025 Issue date: 25 Aug 2022 | 2 May 2022 | 25 Aug 2022 |
| Utility: Shiga toxin a subunit effector polypeptides, Shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation Filling date: 18 Sep 2025 Issue date: 19 Jul 2022 | 7 May 2021 | 19 Jul 2022 |
| Utility: CLINICAL METHODS FOR USE OF A PD-L1-BINDING MOLECULE COMPRISING A SHIGA TOXIN EFFECTOR Filling date: 18 Sep 2025 Issue date: 23 Jun 2022 | 16 Dec 2021 | 23 Jun 2022 |
| Utility: De-immunized, Shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same Filling date: 18 Sep 2025 Issue date: 21 Jun 2022 | 19 Apr 2021 | 21 Jun 2022 |
| Utility: HER2-TARGETING MOLECULES COMPRISING DE-IMMUNIZED, SHIGA TOXIN A SUBUNIT SCAFFOLDS Filling date: 18 Sep 2025 Issue date: 26 May 2022 | 6 Dec 2021 | 26 May 2022 |
| Utility: SHIGA TOXIN A SUBUNIT EFFECTOR POLYPEPTIDES, SHIGA TOXIN EFFECTOR SCAFFOLDS, AND CELL-TARGETING MOLECULES FOR SITE-SPECIFIC CONJUGATION Filling date: 18 Sep 2025 Issue date: 19 May 2022 | 23 Nov 2021 | 19 May 2022 |
| Utility: MHC class I epitope delivering polypeptides Filling date: 18 Sep 2025 Issue date: 26 Apr 2022 | 15 Apr 2021 | 26 Apr 2022 |
| Utility: Multivalent CD20-binding molecule comprising Shiga toxin A subunit effector polypeptides and enriched compositions thereof Filling date: 18 Sep 2025 Issue date: 15 Feb 2022 | 11 Oct 2016 | 15 Feb 2022 |
| Utility: HER2-targeting molecules comprising de-immunized, Shiga toxin A subunit scaffolds Filling date: 18 Sep 2025 Issue date: 18 Jan 2022 | 16 Oct 2020 | 18 Jan 2022 |
| Utility: ADMINISTRATION OF HYPOXIA ACTIVATED PRODRUGS IN COMBINATION WITH IMMUNE MODULATORY AGENTS FOR TREATING CANCER Filling date: 18 Sep 2025 Issue date: 2 Dec 2021 | 26 Jul 2017 | 2 Dec 2021 |
| Utility: PD-L1 TARGETING MOLECULES COMPRISING SHIGA TOXIN A SUBUNIT SCAFFOLDS Filling date: 18 Sep 2025 Issue date: 21 Oct 2021 | 17 Mar 2021 | 21 Oct 2021 |
| Utility: CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same Filling date: 18 Sep 2025 Issue date: 12 Oct 2021 | 10 Mar 2015 | 12 Oct 2021 |
| Utility: PD-L1 -binding molecules comprising Shiga toxin A subunit scaffolds Filling date: 18 Sep 2025 Issue date: 5 Oct 2021 | 21 Sep 2020 | 5 Oct 2021 |
| Utility: CELL-TARGETING MOLECULES COMPRISING DE-IMMUNIZED, SHIGA TOXIN A SUBUNIT EFFECTORS AND CD8+ T-CELL EPITOPES Filling date: 18 Sep 2025 Issue date: 2 Sep 2021 | 12 Apr 2021 | 2 Sep 2021 |
| Utility: Multivalent CD20-binding molecules comprising Shiga toxin a subunit effector regions and enriched compositions thereof Filling date: 18 Sep 2025 Issue date: 31 Aug 2021 | 18 Jul 2019 | 31 Aug 2021 |
| Utility: DE-IMMUNIZED, SHIGA TOXIN A SUBUNIT SCAFFOLDS AND CELL-TARGETING MOLECULES COMPRISING THE SAME Filling date: 18 Sep 2025 Issue date: 19 Aug 2021 | 19 Apr 2021 | 19 Aug 2021 |
| Utility: MHC CLASS I EPITOPE DELIVERING POLYPEPTIDES Filling date: 18 Sep 2025 Issue date: 19 Aug 2021 | 15 Apr 2021 | 19 Aug 2021 |
| Utility: USES OF CD20-BINDING MOLECULES AND ADDITIONAL THERAPEUTIC AGENTS Filling date: 18 Sep 2025 Issue date: 27 May 2021 | 24 Nov 2020 | 27 May 2021 |
| Utility: CELL-TARGETING MOLECULES COMPRISING SHIGA TOXIN A SUBUNIT EFFECTORS AND CD8+ T-CELL EPITOPES Filling date: 18 Sep 2025 Issue date: 13 May 2021 | 25 Jul 2016 | 13 May 2021 |
| Utility: PD-L1-BINDING MOLECULES COMPRISING SHIGA TOXIN A SUBUNIT SCAFFOLDS Filling date: 18 Sep 2025 Issue date: 18 Mar 2021 | 21 Sep 2020 | 18 Mar 2021 |
| Utility: PD-L1-BINDING MOLECULES COMPRISING SHIGA TOXIN A SUBUNIT SCAFFOLDS Filling date: 18 Sep 2025 Issue date: 18 Mar 2021 | 18 Sep 2020 | 18 Mar 2021 |
| Utility: HER2-TARGETING MOLECULES COMPRISING DE-IMMUNIZED, SHIGA TOXIN A SUBUNIT SCAFFOLDS Filling date: 18 Sep 2025 Issue date: 11 Feb 2021 | 16 Oct 2020 | 11 Feb 2021 |
| Utility: CELL-TARGETING MOLECULES COMPRISING PROTEASE-CLEAVAGE RESISTANT, SHIGA TOXIN A SUBUNIT EFFECTOR POLYPEPTIDES AND CARBOXY-TERMINAL MOIETIES Filling date: 18 Sep 2025 Issue date: 21 Jan 2021 | 24 Sep 2020 | 21 Jan 2021 |
| Utility: SHIGA TOXIN A SUBUNIT EFFECTOR POLYPEPTIDES, SHIGA TOXIN EFFECTOR SCAFFOLDS, AND CELL-TARGETING MOLECULES FOR SITE-SPECIFIC CONJUGATION Filling date: 18 Sep 2025 Issue date: 14 Jan 2021 | 7 Dec 2017 | 14 Jan 2021 |
| Utility: Cell-targeting molecules comprising protease-cleavage resistant, Shiga toxin A subunit effector polypeptides and carboxy-terminal moieties Filling date: 18 Sep 2025 Issue date: 27 Oct 2020 | 10 Jun 2015 | 27 Oct 2020 |
| Utility: Predictive biomarker for hypoxia-activated prodrug therapy Filling date: 18 Sep 2025 Issue date: 1 Sep 2020 | 18 Nov 2015 | 1 Sep 2020 |
| Utility: CD38-BINDING PROTEINS COMPRISING DE-IMMUNIZED SHIGA TOXIN A SUBUNIT EFFECTORS Filling date: 18 Sep 2025 Issue date: 23 Jul 2020 | 23 Jan 2020 | 23 Jul 2020 |
| Utility: Aziridine containing DNA alkylating agents Filling date: 18 Sep 2025 Issue date: 2 Jun 2020 | 23 Apr 2019 | 2 Jun 2020 |
| Utility: TH-302 solid forms and methods related thereto Filling date: 18 Sep 2025 Issue date: 19 May 2020 | 16 Nov 2018 | 19 May 2020 |
| Utility: AZIRIDINE CONTAINING DNA ALKYLATING AGENTS Filling date: 18 Sep 2025 Issue date: 19 Mar 2020 | 23 Apr 2019 | 19 Mar 2020 |
| Utility: CELL-TARGETING MOLECULES COMPRISING DE-IMMUNIZED, SHIGA TOXIN A SUBUNIT EFFECTORS AND CD8+ T-CELL EPITOPES Filling date: 18 Sep 2025 Issue date: 23 Jan 2020 | 24 Jan 2018 | 23 Jan 2020 |
| Utility: CD20-BINDING IMMUNOTOXINS FOR INDUCING CELLULAR INTERNALIZATION AND METHODS USING SAME Filling date: 18 Sep 2025 Issue date: 2 Jan 2020 | 12 Sep 2019 | 2 Jan 2020 |
| Utility: METHODS OF SCREENING, SELECTING, AND IDENTIFYING CYTOTOXIC RECOMBINANT POLYPEPTIDES BASED ON AN INTERIM DIMINUTION OF RIBOTOXICITY Filling date: 18 Sep 2025 Issue date: 19 Dec 2019 | 14 Aug 2019 | 19 Dec 2019 |
| Utility: MULTIVALENT CD20-BINDING MOLECULES COMPRISING SHIGA TOXIN A SUBUNIT EFFECTOR REGIONS AND ENRICHED COMPOSITIONS THEREOF Filling date: 18 Sep 2025 Issue date: 28 Nov 2019 | 18 Jul 2019 | 28 Nov 2019 |
| Utility: CD20-binding immunotoxins for inducing cellular internalization and methods using same Filling date: 18 Sep 2025 Issue date: 22 Oct 2019 | 11 Mar 2014 | 22 Oct 2019 |
| Utility: Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity Filling date: 18 Sep 2025 Issue date: 24 Sep 2019 | 4 Feb 2015 | 24 Sep 2019 |
| Utility: Multivalent CD20-binding molecules comprising Shiga toxin A subunit effector regions and enriched compositions thereof Filling date: 18 Sep 2025 Issue date: 27 Aug 2019 | 4 Feb 2016 | 27 Aug 2019 |
