Sale
COUGHLIN TIMOTHY P officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 12,320 $6.83 $84,109 Sale
GRIGORIADIS DIMITRI E. officer: Chief Research Officer officer: Chief Research Officer
Common Stock 12,320 $6.82 $84,072 Sale
VALEUR JENSEN MARGARET E officer: EVP and General Counsel officer: EVP and General Counsel
Common Stock 12,320 $6.83 $84,109 Sale
BOZIGIAN HAIG P. officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 12,320 $6.83 $84,084 Sale
GORMAN KEVIN CHARLES director, officer: Chief Executive Of.. director, officer: Chief Execut..
Common Stock 15,400 $6.83 $105,136 Sale
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 104,000 $2.8 $291,408 Sale
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 94,000 $2.76 $259,252 Sale
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 1,000 $2.7 $2,700 Sale
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 104,000 $2.7 $280,904 Sale
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 77,100 $2.7 $208,324 Sale
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 31,200 $2.7 $84,240 Sale
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 304,800 $2.7 $822,960 Sale
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 88,000 $2.75 $242,352 Sale
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 29,000 $2.75 $79,750 Sale
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 72,000 $2.77 $199,368 Sale
GRIGORIADIS DIMITRI E. officer: Chief Research Officer officer: Chief Research Officer
Common Stock 13,955 $2.53 $35,320 Sale
GORMAN KEVIN CHARLES director, officer: Chief Executive Of.. director, officer: Chief Execut..
Common Stock 15,609 $2.53 $39,491 Sale
OBRIEN CHRISTOPHER FLINT officer: Former Chief Medical Off.. officer: Former Chief Medical O..
Common Stock 13,490 $2.53 $34,103 Sale
COUGHLIN TIMOTHY P officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 12,650 $2.53 $31,967 Sale
VALEUR JENSEN MARGARET E officer: EVP and General Counsel officer: EVP and General Counsel
Common Stock 12,490 $2.53 $31,600 Sale
BOZIGIAN HAIG P. officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 14,090 $2.53 $35,591 Sale
VALEUR JENSEN MARGARET E officer: EVP and General Counsel officer: EVP and General Counsel
Common Stock 8,697 $2.52 $21,943 Sale
GORMAN KEVIN CHARLES director, officer: Chief Executive Of.. director, officer: Chief Execut..
Common Stock 9,445 $2.52 $23,830 Sale
COUGHLIN TIMOTHY P officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 8,697 $2.52 $21,951 Sale
OBRIEN CHRISTOPHER FLINT officer: Former Chief Medical Off.. officer: Former Chief Medical O..
Common Stock 1,503 $2.65 $3,983 Sale
BOZIGIAN HAIG P. officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 751 $2.64 $1,983 Sale
GRIGORIADIS DIMITRI E. officer: Chief Research Officer officer: Chief Research Officer
Common Stock 1,503 $2.67 $4,016 Purchase
MITCHELL W THOMAS director director
Common Stock 900 $2.17 $1,953 Sale
BOZIGIAN HAIG P. officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 3,642 N/A N/A Sale
GRIGORIADIS DIMITRI E. officer: Chief Research Officer officer: Chief Research Officer
Common Stock 3,038 $3.12 $9,463 Sale
OBRIEN CHRISTOPHER FLINT officer: Former Chief Medical Off.. officer: Former Chief Medical O..
Common Stock 4,859 $3.11 $15,131 Sale
GRIGORIADIS DIMITRI E. officer: Chief Research Officer officer: Chief Research Officer
Common Stock 12,606 $3.43 $43,226 Sale
BOZIGIAN HAIG P. officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 12,774 $3.43 $43,776 Sale
COUGHLIN TIMOTHY P officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 12,117 $3.43 $41,537 Sale
OBRIEN CHRISTOPHER FLINT officer: Former Chief Medical Off.. officer: Former Chief Medical O..
Common Stock 12,151 $3.43 $41,666 Sale
VALEUR JENSEN MARGARET E officer: EVP and General Counsel officer: EVP and General Counsel
Common Stock 12,117 $3.43 $41,549 Sale
GORMAN KEVIN CHARLES director, officer: Chief Executive Of.. director, officer: Chief Execut..
Common Stock 15,146 $3.43 $51,920 Purchase
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 9,000 $3.1 $27,882 Purchase
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 6,900 $3.1 $21,383 Purchase
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 25,200 $3.06 $77,087 Purchase
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 75,000 $3.08 $231,150 Purchase
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 7,400 $3.05 $22,585 Sale
GORMAN KEVIN CHARLES director, officer: Chief Executive Of.. director, officer: Chief Execut..
Common Stock 9,195 $3.37 $31,015 Sale
COUGHLIN TIMOTHY P officer: Chief Financial Officer officer: Chief Financial Officer
Common Stock 8,463 $3.39 $28,647 Sale
VALEUR JENSEN MARGARET E officer: EVP and General Counsel officer: EVP and General Counsel
Common Stock 8,463 N/A N/A Sale
BOZIGIAN HAIG P. officer: Chief Development Officer officer: Chief Development Offi..
Common Stock 733 $3.4 $2,489 Sale
OBRIEN CHRISTOPHER FLINT officer: Former Chief Medical Off.. officer: Former Chief Medical O..
Common Stock 1,462 $3.42 $4,993 Sale
GRIGORIADIS DIMITRI E. officer: Chief Research Officer officer: Chief Research Officer
Common Stock 1,462 $3.4 $4,977 Purchase
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 10,600 $2.8 $29,680 Purchase
BVF PARTNERS L P/IL other: See Explanation of Responses other: See Explanation of Respo..
Common Stock 99,400 $2.35 $233,192