Option
GELONE STEVEN P. officer: President and COO officer: President and COO
Restricted Share Units 27,250 N/A N/A Option
GELONE STEVEN P. officer: President and COO officer: President and COO
Ordinary Shares 27,250 N/A N/A Option
CROTTY ROBERT officer: Gen Counsel & Corp Secretary officer: Gen Counsel & Corp Sec..
Restricted Share Units 11,250 N/A N/A Option
CROTTY ROBERT officer: Gen Counsel & Corp Secretary officer: Gen Counsel & Corp Sec..
Ordinary Shares 11,250 N/A N/A Option
SENDER GARY officer: Chief Financial Officer officer: Chief Financial Officer
Restricted Share Units 11,250 N/A N/A Option
SENDER GARY officer: Chief Financial Officer officer: Chief Financial Officer
Ordinary Shares 11,250 N/A N/A Option
LAVINO FRANCESCO MARIA officer: Chief Commercial Officer officer: Chief Commercial Officer
Restricted Share Units 11,250 N/A N/A Option
LAVINO FRANCESCO MARIA officer: Chief Commercial Officer officer: Chief Commercial Officer
Ordinary Shares 11,250 N/A N/A Option
BROOM COLIN MD director director
Restricted Share Units 33,750 N/A N/A Option
BROOM COLIN MD director director
Ordinary Shares 33,750 N/A N/A Purchase
ROWLAND CHARLES A JR director director
Ordinary Shares 53,000 N/A N/A Purchase
BURGESS DANIEL D director director
Ordinary Shares 36,000 N/A N/A Purchase
TALBOT GEORGE HARRISON director director
Ordinary Shares 14,500 N/A N/A Purchase
GELONE STEVEN P. officer: President and COO officer: President and COO
Ordinary Shares 10,000 N/A N/A Purchase
SCHRANZ JENNIFER officer: Chief Medical Officer officer: Chief Medical Officer
Ordinary Shares 5,500 N/A N/A Purchase
BROOM COLIN MD director director
Ordinary Shares 5,000 N/A N/A Purchase
CROTTY ROBERT officer: Gen Counsel & Corp Secretary officer: Gen Counsel & Corp Sec..
Ordinary Shares 10,000 N/A N/A Purchase
SENDER GARY officer: Chief Financial Officer officer: Chief Financial Officer
Ordinary Shares 2,000 N/A N/A Purchase
LAVINO FRANCESCO MARIA officer: Chief Commercial Officer officer: Chief Commercial Officer
Ordinary Shares 2,160 N/A N/A Purchase
BROOM COLIN MD director director
Ordinary Shares F1 10,000 N/A N/A Purchase
WEBSTER STEPHEN W director director
Ordinary Shares 8,000 N/A N/A Purchase
LAVINO FRANCESCO MARIA officer: Chief Commercial Officer officer: Chief Commercial Officer
Ordinary Shares 1,569 N/A N/A Option
TALBOT GEORGE HARRISON director director
Stock Option 1,350 N/A N/A Option
TALBOT GEORGE HARRISON director director
Ordinary Shares 1,350 N/A N/A Purchase
SENDER GARY officer: Chief Financial Officer officer: Chief Financial Officer
Ordinary Shares 2,000 N/A N/A Purchase
BROOM COLIN MD director director
Ordinary Shares 2,588 N/A N/A Purchase
VIVO CAPITAL VIII, LLC 10 percent owner 10 percent owner
Common Stock 52,631 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
Ordinary Shares 3,429 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
Ordinary Shares 22,721 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
Ordinary Shares 10,458 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
Ordinary Shares 639 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
Ordinary Shares 2,013 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
Ordinary Shares 17,790 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
Ordinary Shares 6,585 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
Ordinary Shares 160 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
Ordinary Shares 23,445 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
Ordinary Shares 20,786 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
American Depository Shares representing Common Shares 11,352 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
American Depository Shares representing Common Shares 1,775 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
American Depository Shares representing Common Shares 1,603 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
American Depository Shares representing Common Shares 4,789 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
American Depository Shares representing Common Shares 2,166 N/A N/A Sale
TALBOT GEORGE HARRISON director director
Common Shares 46 N/A N/A Sale
TALBOT GEORGE HARRISON director director
Common Shares 24 N/A N/A Sale
TALBOT GEORGE HARRISON director director
Common Shares 100 N/A N/A Sale
HBM HEALTHCARE INVESTMENTS (CAYMAN) LTD. 10 percent owner 10 percent owner
American Depository Shares representing Common Shares 400 N/A N/A Sale
TALBOT GEORGE HARRISON director director
Common Shares 210 N/A N/A Sale
TALBOT GEORGE HARRISON director director
Common Shares 295 N/A N/A Sale
TALBOT GEORGE HARRISON director director
Common Shares 30 N/A N/A Sale
TALBOT GEORGE HARRISON director director
Common Shares 150 N/A N/A